Photodynamic Treatments For Human Health And The Food Supply

22 March 2018

 - A new field of medical science is emerging from six universities and five partner organizations in Europe. The POLYTHEA project aims to train doctorate candidates in the field of photodynamic treatments. Researchers are learning how to develop active light compounds that fight cancer and microbial infections. The new field of study provides applications for enhancing human health and food preservation.

The project investigates tetrapyrrolic photosensitizers (PS). These are molecules excited by light with the capability of inducing cell death. These photo-excitable molecules cause cell death through the formation of oxygen reactive species but are only toxic in the presence of applied light. These molecules are already being used to treat skin diseases, but improvements can be made to boost efficacy.

Researchers are seeking to find new ways to target specific cells and utilize excitation pathways. They will investigate their bactericidal effects for the removal of biofilms. The research aims to identify new tetrapyrrolic photosensitizers for development of specific anti-cancer, anti-bacterial and anti-inflammatory properties. Some photo-physical properties could be used to stimulate immune system activity. Others could help preserve food and prevent food-borne illness.

One of the discoveries in this field involves the bioluminescence of the firefly or “lightning bug.” These gentle, flying beetles can be seen in the early summer, lighting up the night with their blinking luminescence. Early clinical tests show that firefly light contains a specific substance that can treat skin cancer and cancers lining internal organs.