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Holistic and Natural Alternatives To Antibiotics for Cure of Candidiasis (42 Pages, 613 Citations Research Paper)

Wednesday, June 13, 2018 18:14
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By Kyle J. Norton

What is Candida Albicans

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

Testing Candidiasis

1. Candida spit test(produced by a multi-million dollar corporation, Global Health Trax Inc.)

If you doctor suspects that you have Candida, he/she would ask for a Candida saliva or candida spit test.

With this test, you are asked to place a glass filled clear water by your bed at night.

When you wake in the morning, work up a bit of saliva and spit into it, then check the water every 15 minutes or so for up to one hour.

a) If you have Candida, you will see strings traveling down into the water with the saliva floating on the top, or cloudy saliva sinks to the bottom of the glass, or cloudy specks is suspended in the water.

b) If there is only saliva still floating after at one hour, you have Candida under control.

Unfortunately, according to Vaughter wellness, “One problem with the spit test is that a significant percentage of people who don’t have Candida test “positive”.

A much bigger problem is that a significant percentage of people who do have Candida test negative”(11).

2. Medical test

The medical Candida tests included immunological test of IgG, IgM, IgA, Candida antigen, and immune complexes.

The specimens will be sent to a lab and the results will sent to the doctor in 2- 3 days.

 The doctor will recommend a treatment program, if you are tested positively.

a) Candida Immune Complexes test

It is a blood test to determine if you have had an immune response to Candida albicansa, large presence of these antibodies(15) would indicate a Candida overgrowth(12)(13)(14).

b) Combination of IgA, IgG and IgM tests

b.1. Immunoglobulin A (IgA)(15)(16)(17)

It is an antibody that plays a critical role in mucosal immunity, found in high concentrations in the mucous secretions, including tears, saliva, colostrum and particularly those lining the respiratory passages, gastrointestinal and genitourinary tract.

b.2. Immunoglobulin IgG(15)(16)(17)

It is antibody molecules which correspond to maturation of the antibody response in protecting our body against bacterial and viral infections, found in all body fluids.

b.3. Immunoglobulin IgM(18)(19)

It is a basic antibody that is produced by B cells. The first antibody to appear in response to initial exposure to antigen, found mainly in the blood and lymph fluid.

By analyzing the antibodies in the combination results of all 3 tests, your doctor can determine that you have Candidiasis or not.

Symptoms of Candidiasis

Depending to types and places of infection, you may experience some of the below symptoms.

1. Salivary changes included low hydration level, high saliva viscosity, below-average pH, reduced salivary flow and low saliva buffer capacity, according to “Carol Davila” University of Medicine and Pharmacy(20).

2. Persistence drowsiness

3. Lack of coordination

4. Headaches

5. Mood swing

6. Loss of balance

7. Rashes

8. Mucus in stool

9. Betching and wind

10. Bad breath

11. Dry mouth

12. Postnasal drop

13. Nasal itch and/or congestion

14. Nervous irritability

15. Dry mouth or throat

16. Ear sensitive or fluid in ear

17. Heartburn and indigestion

18. Symptoms worse in damp day

19. Etc.

Risk Factors of Candidiasis

1. Age

Human aging is a biological process. As we age, our immune system is no longer function properly(24)(25) in regulating the balance of microorganisms in the body(22) due to free radicals accumulated(23) over the year.

Through weakening the toll-like receptors which plays an important role in the innate immune system. and natural killer cell may induce the onset or progression of candidiasis(21).

2. Chronic illness

Chronic illness, such as immunodeficiency(29), chronic liver diseases(30), diabetes(31)(32)(34), obesity(33)(34) weakens the defense system in regulating the microorganism(26)(27) in the digestive track, leading to over growth of candida(28).

3. Use of catheters(34)

Catheters is a tube that can be inserted into a body cavity, duct, or vessel allowing drainage, administration of fluids or gases, or access by surgical instruments.

Use of catheter might sometimes provides the candida(35)(36)with a deeper, easy for organisms into the tissue for easy multiplying

4. Inhalant medicine

Repeated use of the steroid inhalant such as residual inhaled corticosteroids (ICSs) on the oral mucosa can result in the development of fungal overgrowth(37)(38) inducing candidiasis(39).

5. Radiotherapy

Candidiasis is also seen in people who have undergone radiotherapy treatment for cancer or as a side effect of certain types of medication(40)(41)(42).

6. Low level of stomach acids

Low level of stomach acids increases the presence of undigested food in the small intestine and colon, causing an overgrowth of harmful bacteria and microorganism, leading to candida(43)(44).

7. Pregnancy

Studies have shown that pregnant women are more susceptible to candida infections(45)(46) than any other time in their lives, due to weakened immune system and changes in hormonal status(47), especially in the second trimester(48).

8. Use of contraceptive pill or hormone replacement therapy

Use of contraceptive pill(49)(50) or hormone replacement therapy(53)(54) promotes the surge in hormones in contributing over growth of candida, resulting in unpleasant symptoms that come along with it.

9. Drug used for controlling intestinal flora

Antibiotic drugs induced antibiotic changes in the bacterial microbiome may lead to C. albicans colonization(55)and exhibit severely impairing digestion(56)(57) and assimilation of nutrients(58) induced fatigue, aggression, depression and toxicity.

9. Women who have sex with women

According to Department of Primary Care and Population Sciences, University College, the odds of candidiasis are proportionally associated to with sexual activity between women(51), as bacterial vaginosis (BV) may be sexually transmitted between women(52).

Causes of Candida Albicans

1. Amalgam filling

Amalgam filling is the use of amalgam as a filling material containing mainly mercury to treat cavity of your teeth by dentist.

As a highly toxic chemical(59)(60), mercury causes damage to the kidneys(61) and central nervous system(62).

Chelation therapy can be effective in removing all forms of mercury from the body(63), but cannot reverse the damage of central nervous system.

As it weakens the immune system(64)(65), it can cause the over growth of bad microorganisms, candidiasis(66)(67).

 

2. Anti fungus drugs

Antifungal drug is a medication used to treat fungal infections and serious systemic infections(68) by exploiting differences between mammalian and fungal cells(69), to kill the fungal organism without dangerous effects on the host(70).

Unfortunately, people successfully treated with antifungal drugs, 5 to 15% develop another infection in the next year(71)(72).

The use of the medication may also cause serious side effects associated with their use, including liver damage(73), weakened immune system(74) and heart failure(75)(76).

 

3. Genetic due to blood types and secretors status

3.1. Genetic mutations

a. People with autosomal dominant hyper-IgE syndrome, due to mutations in signal transducer and activator of transcription1(STAT1)(78)(79), 3 (STAT3), a protein responded to cytokines and growth factors, are at increased risk of mucocutaneous candidiasis caused by percentage of STAT1, STAT3 mutant neutrophils migrating into blisters and in peripheral blood(77)(80).

b. Autoimmune regulator (AIRE) gene

Patient with Autoimmune polyendocrine syndrome type 1 (APS-1) caused by mutations in the autoimmune regulator (AIRE) gene, may susceptible to risk of Chronic mucocutaneous candidiasis, due to Increased IL-17A secretion, mediators of cellular inflammatory responses, in response(81).

3.2. Blood types and secretors status

Secretors status and blood types are defined as a person who secretes their blood type antigens into body fluids and secretions such as the saliva, mucus, etc.

People with certain blood type and secretor status are susceptible to mold allergies and molds.

According to Rambam Medical Center, individuals with blood group O with non-secretors of antigens showed to have a higher carrier frequency of Candida(82)(83).

In dispute of that result, the study by Seoul National University, Korea indicted of no significantly related to blood group or secretor status in oral Candidacarriage(84)

 

4. Steroid in foods

Steroid has been used for commercial profits in order to produce larger food stock both in animals(85) and vegetation(86).

Steroid in foods suppresses the immune response such as medroxyprogesterone acetate (DMPA) in inhibition of innate and adaptive immune mechanisms(87), thereby increasing colonization and promoting the spread of candida(88)(89).

5. Blood sugar imbalance

Blood sugar imbalance caused fluctuation of glucose in the blood stream in patients with diabetes, may lead to Candida albicans overgrowth, due to increased extracellular enzyme activity(90) and production of hydrolytic enzymes(91), as yeast organisms craving for sugar, their natural diet.

6. Immune system deficiency

Immune system deficiency allows candida over growth(92)(93) as it is not longer perform its function in regulating the balance of all microorganism(94) in the intestine track(95)(97).

7. Biochemical and metabolic individually

Slow metabolizers’ bodies chemistry is often more alkaline due to lower production of lactic acid and low levels of gastric hydrochloric acid, leading to constipation(96).

The combination of these factors can result in candida overgrowth(97).

8. Drugs due to suppress immune system during transplant

Drugs suppressing immune system disrupt function of immune system in rpoduction of T cells and phagocytic cells, and the cytokines that mediate the interactions with fungal pathogen(98) and regulation the balance of microorganism in the body(99)(100).

9. Stress

Stress can cause insulin imbalance(101)(102) and weaken the liver(103) and immune function(104), that allow unchecked of over growth candida albicans(105)(106).

10. Deficiency of nutrient

Deficiency of nutrient weakens the body systems in performing their function properly, including the immune system in regulating the balance of microorganism(107)(108).

11. Chronic use of antibiotics

Antibiotic therapy use are known to increase the tendency for chronic infection due its effect in killing bacteria indiscriminately, leading to bad microorganism over growth(109)(110).

12. The pill

The use of the pill can suppress the hormonal balance(111), causing fluctuation of sugar levels(112) and significantly increased risk for candida yeast overgrowth(113).

14. Sexual transmitting diseases

Sex with several partners without precautions increases the risk of candida, if your partner happens to have a candida infection at the time you have sex then you could get it too(114).

15. Acidity

Gastric hydrochloric acid deficiency is widespread and allows yeast to survive passage through the stomach, causing over growth of candidiasis(115)(116).

Continued on read the rest of research paper and resource links, can be found at

https://kylejnorton.blogspot.com/2018/06/the-research-thesis-of-reader-guide-to.html

 

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

 

 

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