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Cobalamin deficiency and spina bifida and other neural tube defects.

Saturday, March 23, 2013 15:24
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Home of Kyle J. Norton for The Better of Living & Living Health Cobalt is one of many essential mineral needed by our body  in very small amounts to enhance productions of red blood cell and the formation of myelin nerve coverings It also is vital as a necessary cofactor for making the thyroid hormone thyroxine and stored in the red blood cells, the plasma,  liver, kidney, spleen, pancreas, etc.
Cobalamin deficiency and spina bifida and other neural tube defects
Cobalamin deficiency in the newborn usually results from cobalamin deficiency in the mother. Megaloblastic anaemia, pancytopenia and failure to thrive can be present, accompanied by neurological deficits if the diagnosis is delayed. According to the study by the the McGill University-Montreal Montreal Children’s Hospital Research Institute of the McGill University Health Center, most cases of spina bifida and other neural tube defects result from maternal folate and/or cobalamin insufficiency in the periconceptual period. Polymorphisms in a number of genes involved in folate and cobalamin metabolism exacerbate the risk. Inborn errors of cobalamin metabolism affect its absorption, (intrinsic factor deficiency, Imerslund-Gräsbeck syndrome) and transport (transcobalamin deficiency) as well as its intracellular metabolism affecting adenosylcobalamin synthesis (cblA and cblB), methionine synthase function (cblE and cblG) or both (cblC, cblD and cblF). Inborn errors of folate metabolism include congenital folate malabsorption, severe methylenetetrahydrofolate reductase deficiency and formiminotransferase deficiency(3).
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