Copper transporters (CTR) and ovarian cancer

Home of Kyle J. Norton for The Better of Living & Living Health Copper is an essential trace element vital to the our health in maintaining the proper functions of the organs and metabolic processes.
Copper transporters (CTR) and ovarian cancer
In the study to investigate Copper transporters (CTR) in regulatiung the cellular transport of platinum drugs, but their role in platinum resistance of ovarian cancer, found that CTR2 expression was increased in chemoresistant patients, but not significantly. However, the CTR2/CTR1 ratio was significantly increased in chemoresistant patients. Cases with positive CTR2 expression or positive CTR2/CTR1 ratio had poor prognoses. When the CTR2 expression in ovarian cancer cells was suppressed, sensitivity to cisplatin was significantly increased. These data suggest that CTR2 contributes to platinum resistance in ovarian cancer. The CTR2/CTR1 ratio is a useful marker for platinum sensitivity and a potential prognostic factor in patients with ovarian cancer(22).
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Sources  
(22) http://www.ncbi.nlm.nih.gov/pubmed/23564780 http://medicaladvisorjournals.blogspot.com