Leukotriene and uterine vascular responses to estrogen

Home of Kyle J. Norton for The Better of Living & Living Health According to the study of Prostaglandins and leukotrienes as inflammatory mediators by John A Salmon and Gerald A Higgs(a), Leukotrienes is produced in leukocytes as a result of oxidative metabolism of arachidonic acid by the enzyme arachidonate 5-lipoxygenase, belonging to the family of eicosanoid inflammatory mediators(a). Its production is usually accompanied by the production of histamine and prostaglandins.
Leukotriene and  uterine vascular responses to estrogen
In the study to test hypothesis of that the leukotrienes may be the mediators of the uterine vascular responses to estrogen, by giving FPL 55712, a selective leukotriene antagonist, to estrogen-primed, nonpregnant rabbits and measured regional blood flows by the radioactive microsphere technique, indicated that leukotrienes do not mediate, but rather inhibit, the uterine vascular responses to estrogen(26).
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Sources
(a) http://bmb.oxfordjournals.org/content/43/2/285   
(26) http://www.ncbi.nlm.nih.gov/pubmed/6695994  http://medicaladvisorjournals.blogspot.com