Blueberry Muffin Jubilee and Savory Black Soybean Loaf and The Main Ingredients Health Benefits

Home of Kyle J. Norton for The Better of Living & Living Health I. The recipe

II. The Main Ingredients Health Benefits
II.A.  Blueberries
Blueberry is a flower plant, belong to the family Eriaceae and native to Northern America. It can grows from 10 cm to 4 meters tall.

Nutritients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A
6. Lutein and zeaxanthin
7. Thiamine (Vitamin B1)
8. Riboflavin (Vitamin B2)
9. Niacin (Vitamin B3)
10. Pantothenic acid (Viamin B5)
11. Vitamin B6
12. Folate (Vitamin B9)
13. Vitamin C
14. Vitamin E
15. Calcium
16. Iron
17. Magnesium
18. Phosphorus
19. Potassium
20. Zinc
21. Manganese
22. Vitamin K
23. Etc.

Health Benefits
A. Health benefits according to studies
1. Antioxidant Capacity
In the investigation of Blueberry and blackberry wines commercially available in Illinois and theirs potential health benefits, found that fruit wines made from blueberries and blackberries may have potential health applications and therefore could contribute to the economy of the wine industry. Practical Application: The majority of wines are produced from grapes, but wine can also be produced from other fruits including blueberries and blackberries, which contain phenolic compounds that may contribute to human health, according to “Comparison of Chemical Composition and Antioxidant Capacity of Commercially Available Blueberry and Blackberry Wines in Illinois” by Johnson MH, Gonzalez de Mejia E.(a)

2. Inflammatory bowel diseases
In the study of blueberries and broccoli in mdr1a(-/-) mice (IBD mouse model) for theirs effect gastrointestinal tract, found that blueberry- and broccoli-supplemented diets increased colon crypt size and the number of goblet cells per crypt. Only the broccoli-supplemented diet significantly lowered colonic inflammation compared to mice fed the control diet, according to “Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a(-/-) mice, a model of inflammatory bowel diseases” by Paturi G, Mandimika T, Butts CA, Zhu S, Roy NC, McNabb WC, Ansell J.(b)

3. Anti cancers
In the assessment of Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) primarily found in blueberries and its anti cancer effects found that pterostilbene inhibits cancer growth through alteration of the cell cycle, induction of apoptosis, and inhibition of metastasis. In vivo, pterostilbene inhibits tumorigenesis and metastasis with negligible toxicity. Pterostilbene has also been shown to be effective as an inducer of antioxidant capacity in multiple cancer cell lines that may facilitate its function as an anticarcinogenic compound, according to “Pterostilbene and Cancer: Current Review” by McCormack D, McFadden D.(c)

4. Metabolic Syndrome
In the classification of therapeutic roles of strawberries, blueberries, and cranberries in metabolic syndrome found that strawberries lowering total and LDL-cholesterol, but not triglycerides, and decreasing surrogate biomarkers of atherosclerosis (malondialdehyde and adhesion molecules); blueberries lowering systolic and diastolic blood pressure and lipid oxidation and improving insulin resistance; and low-calorie cranberry juice selectively decreasing biomarkers of lipid oxidation (oxidized LDL) and inflammation (adhesion molecules) in metabolic syndrome, according to “Strawberries, Blueberries, and Cranberries in the Metabolic Syndrome: Clinical Perspectives” by Basu A, Lyons TJ.(d)

5. Cardiovascular diseases
In the determination of polyphenols, especially anthocyanins, micronutrients, and fiber in berries, including to chokeberries, cranberries, blueberries, and strawberries found that purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism. Benefits were seen in healthy subjects and in those with existing metabolic risk factors. Underlying mechanisms for these beneficial effects are believed to include upregulation of endothelial nitric oxide synthase, decreased activities of carbohydrate digestive enzymes, decreased oxidative stress, and inhibition of inflammatory gene expression and foam cell formation. Though limited, these data support the recommendation of berries as an essential fruit group in a heart-healthy diet, according to “ Berries: emerging impact on cardiovascular health” by Basu A, Rhone M, Lyons TJ.(e)

B. Health benefits according to concentration
1. Vitamin KVitamin K not only plays an important role in protecting our skin from aging, it is also needed for the proper clotting of blood, thus decreasing the risk of excessive bleeding, in a study of “Delayed vitamin K deficiency as a cause of bleeding: still a concern in the 21st century!” by Kasatkar P, Shetty S, Ghosh K., posted in PubMed, researchers found that Laboratory tests confirmed acquired bleeding diathesis due to vitamin K deficiency, which was corrected after adequate vitamin K supplementation. VKDB is not an uncommon phenomenon and should be considered in the differential diagnosis of a child with bleeding diathesis.
2. ManganeseManganese beside plays an vital role for the proper and normal growth of human bone structure (accodring to the study of “Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants” by Pabbruwe MB, Standard OC, Sorrell CC, Howlett CR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15109850)), it also helps to reduce the risk of cancer, (according to the study of “The effects of 3, 4 or 5 amino salicylic acids on manganese-induced neuronal death: ER stress and mitochondrial complexes” by Yoon H, Lee GH, Kim DS, Kim KW, Kim HR, Chae HJ., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21477646 researchers indicated that the salicylate analogues and the antioxidants did not mediate ER stress in this model. The salicylate analogues reduced reactive oxygen species (ROS) and reversed the deficient mitochondrial membrane potential that was induced by Mn. Taken together, the 3, 4, 5 ASA worked in a similar way, regulating the Mn-induced mitochondrial dysfunction and protecting cells.

3. Vitamin Ca. Asthma
Vitamin C is one of the key antioxidant vitamins which is abundant in the extracellular fluid lining the lung and low vitamin C intake has been associated with pulmonary dysfunction, such as asthma, according to the study of “Vitamin C supplementation for asthma” by Kaur B, Rowe BH, Arnold E.(1)

b. DNA Damage
Ascorbic acid (AA), known as vitamin C, has important antioxidant vitamin has exerted the activity in preventing (imazalil)IMA-induced cause of DNA damage, according to the stuyd of “The protective role of ascorbic acid on imazalil-induced genetic damage assessed by the cytogenetic tests’ by Türkez H, Aydin E.(2)

4. Dietary fiberDaily intake of right amount of fibers can prvent and treata. Diabetes, as Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of “Efficacy of high-fiber diets in the management of type 2 diabetes mellitus” by Wolfram T, Ismail-Beigi F.(3)

5. Etc.

C. Other health benefits1. Cardiovascular diseases
Since blue berry contains high amount of antioxidant, it reduces ROS production and the effects of oxidative stress due to ROS, apoptosis and improve cardiac function, according to “Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases” by Subramanian S, Kalyanaraman B, Migrino RQ.(I)

2. Alzheimer’s disease
Anthocyanin has been shown to boost the communication between failing brain neuronssame brain plaque which afflicts Alzheimer’s disease victims, by enhanced memory-associated neuronal signaling and alterations involved in certain neuronal activities that can help to overcome genetic predisposition to Alzheimer’s Disease, according to “Protective effects of anthocyanins against amyloid β-peptide-induced damage in neuro-2A cells” by Shih PH, Wu CH, Yeh CT, Yen GC.(II)

3. Urinary tract infections
Urinary tract infections is an irritating and painful recurring probe. Blue berry contains proanthocyanidins, the anitoxidant stops bacteria from attaching to the lining of the bladder and enhances the bladder to flush them out through urinary expelling, acoridng to “Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections” by Lavigne JP, Vitrac X, Bernard L, Bruyere F, Sotto A.(III)

4. Anti tumors and cancers
Antioxidant in blueberry promotes the proper DNA replication and cells division, thus reducing the risk of free radicals causes of tumors and cancers, according to “Free radicals, metals and antioxidants in oxidative stress-induced cancer” by Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M.(IV)

5. Etc.

Side effects
1. Oxalates
Oxalates can cause health problem for people with untreated kidney and gallbladder diseases.
2. It may interfere with the absorption of calcium.
3. Cause kidney stone
4. Etc.

II. Organic Soybean
Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with suitable climate for commercial profit and a a healthy foods.

Nutrients1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.

Health benefits
A. Health Benefits according to studies1. Insulin sensitive
Soybean helps to normalize plasma glucose and insulin homeostasis, according to “Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content” by Nordentoft I, Jeppesen PB, Hong J, Abudula R, Hermansen K.(a)

2. Cardiovascular diseasesSoy protein reduces reduces the levels of serum lipoprotein, decrease in low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), LDL-C/high-density lipoprotein cholesterol (HDL-C), triacylglycerol/HDL-C and TC/HDL-Cpostmenopausal women are at risk of cardiovascular disease, according to “Effects of soy bean on serum paraoxonase 1 activity and lipoproteins in hyperlipidemic postmenopausal women” by Shidfar F, Ehramphosh E, Heydari I, Haghighi L, Hosseini S, Shidfar S.(b)

3. Adipogenesis and AdipolysisGerminated soy bean protein hydrolysates had an effect on inhibition of lipid storage in adypocites and increasing lipolysis, according to “Effect of Germinated Soybean Protein Hydrolysates on Adipogenesis and Adipolysis in 3T3-L1 Cells” by González-Espinosa de Los Monteros LA, Ramón-Gallegos E, Torres-Torres N, Mora-Escobedo R.(c)

4. Antioxidant effectsExtract from Virginia-grown soybean seeds had exerted its antioxidant effect when compared for their total phenolic contents (TPC), oxygen radical absorbance capacity (ORAC), and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(*)) scavenging activities, according to “Comparison of different strategies for soybean antioxidant extraction” by Chung H, Ji X, Canning C, Sun S, Zhou K.(d)

5. Diabetes and hypertension
Soybean phenolic-rich extracts has exerted the inhibitory activities of phenolic-rich extracts from soybean on α-amylase, α-glucosidase and angiotensin I converting enzyme (ACE) activities in vitro, according to “Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro” by Ademiluyi AO, Oboh G.(e)

B. Health Benefits according to the concentration
1. MolybdenumMolybdenum cofactor is vital for human enzymes, including xanthine oxidase, sulfite oxidase, and aldehyde oxidase, Deficiency may cause Prenatal brain disruption, according to the study of “Prenatal brain disruption in molybdenum cofactor deficiency” by Carmi-Nawi N, Malinger G, Mandel H, Ichida K, Lerman-Sagie T, Lev D.(1)

2. TryptophanTryptophan beside is the precosur of serotonin as it is famous in inducing sleep if it taken in high dose,according to the study of “Improving the quality of infant sleep through the inclusion at supper of cereals enriched with tryptophan, adenosine-5′-phosphate, and uridine-5′-phosphate” by Cubero J, Chanclón B, Sánchez S, Rivero M, Rodríguez AB, Barriga C.(2), it also enhances the neural responses cayused by depression, according to the study of “The effects of tryptophan depletion on neural responses to emotional words in remitted depression” by Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC.(3)

3. ManganneseIt is one of important trace in preventing osteroposis, according to the study of “[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]” by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(4)and regulating blood sugar level, according to the study of “[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]” by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(5)

4. ProteinProtein in Soybean is not only beneficial to the cardiovascular diseases, according to the study of “Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee” by Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M; American Heart Association Nutrition Committee(6), but also plays an important role in treating diabetes, according to “Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes” by Liu ZM, Chen YM, Ho SC, Ho YP, Woo J.(7)

C. Other health benefits
1. Aspartic acidAspartic acid not only helps to protect the body from drug toxicity and radiation, it also plays an essential role for the brain in information transmitting across the synapse, thus enhancing the learning and memory mechanism, according to the study of “Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific” by Ormond J, Woodin MA., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21954377

2. HistidineHistidine plays an important role in promoting white and red blood cells, thus increasing the immune system in fight against forming of free radical and reducing the risk anemia., according to the study of “The role of histidine in the anemia of folate deficiency” by Cooperman JM, Lopez R., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/12486209), researchers concluded that concluded that folate deficiency causes histidine depletion through increased urinary excretion of this amino acid. Feeding histidine replenishes tissue levels of histidine, resulting in hemoglobin regeneration. Folic acid administration results in return of histidine to normal urinary levels. Thus, a combination of folic acid histidine would be beneficial for folate deficient individuals.

3. SerineAs an amino acid, serine in soybean not only helps to maintain proper muscle build up by synthesizing fatty acids and proteins, it also is important for brain in to transport information between themselves and cells in other parts of the body, according to the study of “Transport systems of serine at the brain barriers and in brain parenchymal cells” by Kasai Y, Tachikawa M, Hirose S, Akanuma S, Hosoya K., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/21592122)

4. AlanineAlanine not only is essential in production of energy in glucose synthesis (according to the study ofGlucose and insulin effects on the novo amino acid synthesis in young men: studies with stable isotope labeled alanine, glycine, leucine, and lysine” by Robert JJ, Bier DM, Zhao XH, Matthews DE, Young VR., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/6815417) it also enhances the immune system in production of anti bodies., according to the study of “The immune response of tetraparental mice to two synthetic amino acid polymers: “high-conjugation” 2,4 dinitrophenyl-glutamic acid57-lysine38-alanine5 (DNP-GLA5) and glutamic acid60 alanine30 tyrosine10 (GAT10)” by Warner CM, Fitzmaurice M, Maurer PH, Merryman CF, Schmerr MJ., posted in The Journey of Immunology (http://www.jimmunol.org/content/111/6/1887)

5. IsoleucineAnother animo acid helps to maintain the body tissues and store glycogen in muscles thereby reducing the risk of muscle breaking down during physical activity., according to the study of “Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes” by Doi M, Yamaoka I, Fukunaga T, Nakayama M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/14651987), researchers that isoleucine stimulates the insulin-independent glucose uptake in skeletal muscle cells, which may contribute to the plasma glucose-lowering effect of isoleucine in normal rats.

Side effect1. Toxicity
Raw soybeans, including the immature green form, are toxic.
2. Etc.

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For the world most healthy foods lists, visit http://healthy-foods-index.blogspot.com/2011/03/healthy-foods-list.html,
For other health articles, please visit http://medicaladvisorjournals.blogspot.ca

Sources of Blueberries
 (a) http://www.ncbi.nlm.nih.gov/pubmed/22182198
(b) http://www.ncbi.nlm.nih.gov/pubmed/22113065
(c) http://www.ncbi.nlm.nih.gov/pubmed/22099605
(d) http://www.ncbi.nlm.nih.gov/pubmed/22082311
(e) http://www.ncbi.nlm.nih.gov/pubmed/20384847(1) http://www.ncbi.nlm.nih.gov/pubmed/19160185
(2) http://www.ncbi.nlm.nih.gov/pubmed/21986888
(3) http://www.ncbi.nlm.nih.gov/pubmed/20713332

(I) http://www.ncbi.nlm.nih.gov/pubmed/19807685
(II) http://www.ncbi.nlm.nih.gov/pubmed/21302893
(III) http://www.ncbi.nlm.nih.gov/pubmed/22126300
(IV) http://www.ncbi.nlm.nih.gov/pubmed/16430879

Sources of Organic Soybean
(a) http://www.ncbi.nlm.nih.gov/pubmed/18522411
(b) http://www.ncbi.nlm.nih.gov/pubmed/18608549
(c) http://www.ncbi.nlm.nih.gov/pubmed?term=Effect%20of%20Germinated%20Soybean%20Protein%20Hydrolysates%20on%20Adipogenesis%20and%20Adipolysis%20in%203T3-L1%20Cells
(d) http://www.ncbi.nlm.nih.gov/pubmed/20302378
(e) http://www.ncbi.nlm.nih.gov/pubmed/22005499

(1) http://www.ncbi.nlm.nih.gov/pubmed/21285035
(2) http://www.ncbi.nlm.nih.gov/pubmed/19925721
(3) http://www.ncbi.nlm.nih.gov/pubmed/19539268
(4) http://www.ncbi.nlm.nih.gov/pubmed/12870295
(5) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(6) http://www.ncbi.nlm.nih.gov/pubmed/16418439
(7) http://www.ncbi.nlm.nih.gov/pubmed/20335543 http://medicaladvisorjournals.blogspot.com