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A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis

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Home of Kyle J. Norton for The Better of Living & Living Health Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).
Migraine headache is one most common headaches defined as condition of chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes and affected over 15% of the population in US alone, as a result of the change in the brain and its surrounding blood vessels.
A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis
In a randomized double-blind placebo-controlled trial of a compound providing a daily dose of riboflavin 400 mg, magnesium 300 mg, and feverfew 100 mg with the placebo contained 25 mg riboflavin. The study included a 1-month run-in phase and 3-month trial. The protocol allowed for 120 patients to be randomized, with a preplanned interim analysis of the data after 48 patients had completed the trial, showed that Riboflavin 25 mg showed an effect comparable to a combination of riboflavin 400 mg, magnesium 300 mg, and feverfew 100 mg. The placebo response exceeds that reported for any other placebo in trials of migraine prophylaxis, and suggests that riboflavin 25 mg may be an active comparator. There is at present conflicting scientific evidence with regard to the efficacy of these compounds for migraine prophylaxis(8).
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Sources
(a) http://en.wikipedia.org/wiki/Magnesium    
(8) http://www.ncbi.nlm.nih.gov/pubmed/15447697  http://medicaladvisorjournals.blogspot.com


Source: http://medicaladvisorjournals.blogspot.com/2013/09/a-combination-of-riboflavin-magnesium.html



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