Antenatal glucocorticoid, magnesium exposure, and the prevention of brain injury of prematurity
Home of Kyle J. Norton for The Better of Living & Living Health Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).
Antenatal glucocorticoid, magnesium exposure, and the prevention of brain injury of prematurity
Prevention of perinatal white matter injury with or without severe intraventricular hemorrhage (IVH) is critical to reduce cerebral palsy (CP) in premature infants. According to the study by the UT Southwestern Medical School, Dallas, , antenatal therapies that may afford neuroprotection include glucocorticoids, which are associated with a significant reduction in severe IVH, and magnesium, which is associated with reduced CP. Potential protective mechanisms of glucocorticoids include a direct effect on brain, improved respiratory function, and more stable blood pressure hemodynamics. Because magnesium is often administered to mothers with pregnancy-induced hypertension, a condition associated with reduction in severe IVH, the independent neuroprotective role of magnesium remains unclear and warrants additional studies(8).
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Sources
(a) http://en.wikipedia.org/wiki/Magnesium
(8) http://www.ncbi.nlm.nih.gov/pubmed/9777678 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/antenatal-glucocorticoid-magnesium.html
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