The anti-ageing potential of a new jasmonic acid derivative

Home of Kyle J. Norton for The Better of Living & Living Health Human aging is a biological process, no one can stop, but delay it.
Dihydroquercetin (taxifolin) is a potent flavonoid found in onions, French maritime bark, milk thistle, tamarind seeds and commercially available semi-synthetic monoHER marketed as Venoruton(a).
Jasmonic acid
Jasmonic acid is derived from the fatty acid linolenic acid. It is a member of the jasmonate class of plant hormones(a). 
The anti-ageing potential of a new jasmonic acid derivative (LR2412)
In the real time RTQPCR  to detemine the effect of a jasmonic acid derivative, tetra-hydro-jasmonic acid (LR2412, 1 and 10 μm)  in vitro reconstructed skin model, Episkin™, showed that an increase in hyaluronan synthase 2 (HAS2) and hyaluronase synthase 3 (HAS3) expression. Furthermore, an increase in hyaluronic acid (HA) deposits in basal and suprabasal layers of the epidermis was observed. The percentage of positive Ki67 keratinocytes in the basal layer as well as the epidermis thickness were seen to increase. Immunohistochemistry studies showed that the synthesis of late differentiation proteins filaggrin and transglutaminase 1 was not modified. The human epidermis is known to thin with age while HA content has been reported to decrease. These results illustrate the potential of LR2412 in counteracting signs of skin ageing(1).
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Sources
(a) http://en.wikipedia.org/wiki/Jasmonic_acid
(1) http://www.ncbi.nlm.nih.gov/pubmed/22509841

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