A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts
Home of Kyle J. Norton for The Better of Living & Living Health Adrenocorticotropic hormone (ACTH) or corticotropin, is a hormone produced by the anterior pituitary gland in response to biological stress by effecting the increased production and release of corticosteroids(a)
A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts
In the study to to assess the effects of endogenous CRH in the biology of mouse and human skin fibroblasts, the primary cell type involved in wound healing, showed that expression of CRH and its receptors in primary fibroblasts, and we demonstrate the functionality of fibroblast CRH receptors by induction of cAMP. Fibroblasts genetically deficient in Crh (Crh-/-) had higher proliferation and migration rates and compromised production of IL-6 and TGF-β1 compared to the wildtype (Crh+/+) cells. Human primary cultures of foreskin fibroblasts exposed to the CRF(1) antagonist antalarmin recapitulated the findings in the Crh-/- cells, exhibiting altered proliferative and migratory behavior and suppressed production of IL-6(17).
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Sources
(a) http://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
(17) http://www.ncbi.nlm.nih.gov/pubmed/21765902 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/10/a-novel-role-of-peripheral.html
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