May primary empty sella turcica be a cause of isolated ACTH deficiency

Home of Kyle J. Norton for The Better of Living & Living Health Adrenocorticotropic hormone (ACTH) or corticotropin, is a  hormone produced by the anterior pituitary gland in response to biological stress by effecting the increased production and release of corticosteroids(a)
May primary empty sella turcica be a cause of isolated ACTH deficiency
Isolated ACTH deficiency is an uncommon cause of secondary adrenocortical insufficiency and accompaniment with primary empty sella has been reported in several case. There is a report of a case of isolated ACTH deficiency associated with empty sella. A sixty-two year old woman was admitted to our endocrine clinic with complaints of weakness, fatigue, weight loss, nausea, vomiting, and lack of appetite for about one month. Physical examination indicated orthostatic hypotension and epigastric tenderness. Although cranial and abdominal computerized tomography images were evaluated as normal, cranial magnetic resonance imaging of the pituitary gland revealed ‘primary empty sella turcica’. Replacement therapy with methylprednisolon resulted in the improvement of hypoglycemia, hyponatremia and clinical symptoms. Based on these results, the patient was diagnosed as isolated ACTH deficiency and was scheduled for follow up by our outpatient clinic(19).
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Sources
(a) http://en.wikipedia.org/wiki/Adrenocorticotropic_hormone   
(19) http://www.ncbi.nlm.nih.gov/pubmed/18063931  http://medicaladvisorjournals.blogspot.com