The World’s First 3-Parent-Baby Has Arrived

The world’s first 3-parent baby was born into the world 5 months ago, but the news was only announced on September 27. [1]

The infant was born April 6, to Ibtisam Shaban and Mahmoud Hassan, but he carries the DNA of 3 parents. The Jordanian couple were given the ground-breaking treatment by a US team in Mexico. The new parents had been trying to start a family for 20 years. [2]

Abrahim’s mother, Ibtisam, carries the genes for Leigh syndrome, a fatal disorder that affects the central nervous system. According to the National Institutes of Health (NIH), the syndrome “is characterized by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within two to three years, usually due to respiratory failure.”

Leigh disorder usually becomes apparent during the first year of life, but some people don’t develop symptoms until adulthood. [3]

The genes for the disease are housed in the DNA’s mitochondria, which provide energy for the cells and carry 37 genes that are passed down on the mother’s side.

Approximately 1/4 of Shaban’s genes carry the disease-causing mutation, which killed her first 2 children. One child lived to be 6 years old, while the 2nd child only lived 8 months. [4]

The Procedure

The couple sought the help of John Zhang and his team at the New Hope Fertility Center in New York City. Zhang is one of the first engineers of the “3-parent” technique, which can be accomplished a few ways.

In the United Kingdom, the procedure is called pronuclear transfer and involves fertilizing both the mother’s egg and a donor egg with the father’s sperm. Each nucleus is removed from the eggs before they can start dividing into early-stage embryos. From there, the nucleus from the donor’s fertilized egg is discarded and replaced by that from the mother’s fertilized egg.

However, Shaban and Mahmoud opposed the destruction of 2 embryos due to their Muslim faith. So, Zhang used a procedure called spindle nuclear transfer. He removed the nucleus from one of Shaban’s eggs and inserted it into a donor egg that had its own nucleus removed. The resulting egg – with nuclear DNA from the mother and mitochondrial DNA from a donor – was then fertilized with the father’s sperm.

In total, 5 embryos were created from the procedure, but only 1 developed normally. The surviving embryo was implanted in Shaban and the child was born 9 months later.

Zhang had to perform the procedure in Mexico, because spindle nuclear transfer is not approved in the United States; however, pronuclear transfer is.

Sian Harding, who reviewed the ethics of the UK procedure, said it appeared to be an ethical process. The team did not destroy any embryos, and a male embryo was used so that the resulting child would not pass on any inherited mitochondrial DNA. Said Harding:

“It’s as good as or better than what we’ll do in the UK.”

Lingering Concerns

The 3-parent technique was first attempted in the 1990’s.

The last time embryologists tried to create a baby from 3 parents’ DNA, the injected mitochondrial DNA from a donor was injected into another woman’s egg, along with sperm from her partner. Sadly, some of the babies went on to develop genetic disorders. This resulted in the technique being banned. It’s possible the problem arose from the babies having mitochondria from 2 sources.

When Zhang and his team tested Abrahim’s mitochondria, they found that less than 1% carry the mutation. They hope that’s too low to cause any problems. It typically takes about 18% of mitochondria to be affected for genetic disorders to emerge.

Bert Smeets at Maastricht University in the Netherlands said the team should monitor the child to make sure that number doesn’t rise. It’s not beyond the realm of possibility that faulty mitochondria could be better at replicating, and gradually increase in number.

Read: Biotech is Creating GMO Human Babies: What Could Possibly go Wrong?

Said Smeets:

“We need to wait for more births, and to carefully judge them.”

He added:

“A US-based research group apparently escaped the more rigid regulatory framework in the US to perform this treatment in Mexico. That is a concern, especially as the framework not only safeguards the introduction into the clinic, but also the follow-up of the children borne after this treatment.

Hopefully, now the first child is born and the heat is off, it takes away the pressure to involve patients in unsecured treatments, when good alternatives are available.” [2]

Sources:

[1] Mirror

[2] The Telegraph

[3] National Institutes of Health

[4] New Scientist

The Telegraph

The Straits Times