By significantly increasing the speed of functional MRI (fMRI), researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have been able to image rapidly fluctuating brain activity during human thought. fMRI measures changes in blood oxygenation, which were previously thought to be too slow to detect the subtle neuronal activity associated with higher order brain functions.
fMRI signals in the brain’s visual cortex as an individual views the checkerboard stimulus. The green, blue and dark blue spots represent signals produced within a fraction of a second after stimulation with dark blue being the fastest responding areas.
“A critical aim of the President’s BRAIN Initiative is to move neuroscience into a new realm where we can identify and track functioning neural networks non-invasively,” explains Guoying Liu, Ph.D., Director of the NIBIB program in Magnetic Resonance Imaging. “This work demonstrates the potential of fMRI for mapping healthy neural networks as well as those that may contribute to neurological diseases such as dementia and other mental health disorders, which are significant national and global health problems.”
fMRI works by detecting local increases in oxygen as blood is delivered to a working part of the brain. The technique has been instrumental for identifying which areas in the brain control functions such as vision, hearing, or touch.
Display presented to participants to stimulate the visual cortex
Combining several new techniques, Jonathan R. Polimeni, Ph.D., senior author of the study, and his colleagues at Harvard’s Athinoula A. Martinos Center for Biomedical Imaging, applied fast fMRI in an effort to track neuronal networks that control human thought processes, and found that they could now measure rapidly oscillating brain activity. The results of this groundbreaking work are reported in the October 2016 issue of the Proceedings of the National Academy of Sciences.
The researchers used fast fMRI in human volunteers observing a rapidly fluctuating checkerboard pattern. The fast fMRI was able to detect the subtle and very rapid oscillations in cerebral blood flow in the brain’s visual cortex as the volunteers observed the changing pattern.
One such possibility is suggested by first author of the study Laura D. Lewis, Ph.D. “This technique now gives us a method for obtaining much more detailed information about the complex brain activity that takes place during sleep, as well as other dynamic switches in brain states, such as when under anesthesia and during hallucinations.”
Concludes Polimeni, “It had always been thought that fMRI had the potential to play a major role in these types of studies. Meaningful progress in cognitive neuroscience depends on mapping patterns of brain activity, which are constantly and rapidly changing with every experience we have. Thus, we are extremely excited to see our work contribute significantly to achieving this goal.”
The results of this work contributed to Dr. Polimeni’s recent grant award from the NIH BRAIN Initiative. The BRAIN funding will be used to extend studies using fast fMRI to continue improvement in the fine scale mapping of human brain function.
The work was funded by the National Institutes of Health (NIH) through grants EB011498, EB019437, and EB015896 from the National Institute for Biomedical Imaging and Bioengineering. Additional funding was provided by several NIH Shared Resource Instrumentation Grants, and the Athinoula A. Martinos Center for Biomedical Imaging.
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. www.braininitiative.nih.gov