Mystery Cracked: Why Infections Don't Spread Uncontrollably from Wounds

The researchers have discovered that fragments of thrombin – a common blood protein which can be found in wounds – can aggregate both bacteria and their toxins; something they did not see in normal blood plasma. The aggregation takes place quickly in the wound and causes bacteria and endotoxins not only to gather but also to be “eaten” by the body’s inflammatory cells.

“This way, the body avoids a spread of the infection. We believe this to be a fundamental mechanism for taking care of both bacteria and their toxins during wound healing”, says Jitka Petrlova and continues;

“Our discovery links aggregation and amyloid formation to our primary defence against infections – our innate immunity. It is well known that various aggregating proteins can cause amyloid disease, in skin or internal organs, such as the brain. Therefore, a mechanism that is supposed to protect us from infections, can sometimes be over-activated and lead to degenerative diseases.”

Artur Schmidtchen, who has conducted research in the field of innate immunity for over 20 years, is pleased with the results of the study.

“I have always been fascinated by how nature has effectively created different defence mechanisms, and wound healing provides a rich source of new discoveries. The ability to effectively heal wounds is of evolutionary significance to our survival. Compared to antibiotics, innate immunity has been around for millions of years – and I think we should consider the application of these concepts in an era of increasing antibiotic resistance.”

Contacts and sources:
Artur Schmidtchen, MD., PhD., Professor
Department of Clinical Sciences, Division of Dermatology and Venereology; Lund University and Consultant at Skåne University Hospital, Sweden