Nanoparticles Can Travel from Lungs to Blood, Possibly Explaining Risks to Heart
In the new study, 14 healthy volunteers, 12 surgical patients and several mouse models inhaled gold nanoparticles, which have been safely used in medical imaging and drug delivery. Soon after exposure, the nanoparticles were detected in blood and urine. Importantly, the nanoparticles appeared to preferentially accumulate at inflamed vascular sites, including carotid plaques in patients at risk of a stroke.
The findings suggest that nanoparticles can travel from the lungs into the bloodstream and reach susceptible areas of the cardiovascular system where they could possibly increase the likelihood of a heart attack or stroke, the researchers say.
The authors acknowledge funding from the British Heart Foundation, the Colt Foundation, the Netherlands’ Ministry of Infrastructure and Environment and the U.K. Department of Health.
Katie Cottingham,Ph.D.
American Chemical Society
ACS Nano
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