Cannabis, 'Spice' -- Better Think Twice: Cannabinoids Induce Seizures by Acting Through the Cannabinoid CB1 Receptor
Research led by Olga Malyshevskaya and Yoshihiro Urade of International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, discovered that seizures, a life-threatening condition, can be induced by natural Δ9-tetrahydrocannabinol (Δ9-THC, main constituent of marijuana) or the synthetic cannabinoid JWH-018 (main component of synthetic blend “Spice”) in mice. This was demonstrated by continuous recording of animals’ electric brain activity (electroencephalogram, EEG), video and movement activity tracking. Based on their data they propose potential treatment in case of cannabinoid overdose with the cannabinoid-1-receptor (CB1R) specific antagonist (AM-251), because in their study pretreatment prevented cannabinoid-induced seizures.
Credit: University of Tsukuba
Considering the recent irreversible spread of synthetic cannabinoids and their impact on human health, their data should serve as a public alert. It is critically important for health-care professionals and policy makers to be aware of the serious adverse effects, as shown in this report. Clinicians in the emergency departments should always suspect seizure activity in patients who have a history of cannabinoid intoxication. The number of clinical cases involving marijuana intoxication has been steadily increasing due to increase in cannabis potency over the last two decades.
Reflecting the scientific debate on the action of cannabinoids, there are numerous disputes regarding the legal status of marijuana. As several governments proceed with legalization for both medical and recreational use, there will always be public health concerns, as marijuana overdose often results in direct adverse reactions.
Contacts and sources:
Masataka Sasabe
University of Tsukuba
Citation: Malyshevskaya O, Aritake K, Kaushik MK, Uchiyama N, Cherasse Y, Kikura-Hanajiri R, Urade Y. (2017) Natural (△9-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Scientific Reports 7: 10516.
doi:10.1038/s41598-017-10447-2 http://dx.doi.org/10.1038/s41598-017-10447-2
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Whistler Blowers, Insiders
Marijuana might be the second most abuses drug in the world, but alcohol is numero uno, I am pretty sure.
“Legitimate” people, using legal drugs, judge dissidents, using street drugs, and vice versa.
If you want to be intellectually honest, you would have to say that either has a benefit to society and a social cost.
Re-sale doesn’t cover the cost of overhead. So, I see it as a plot.