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Better Than Chemo DuP-697 in Inhibited Immune Suppressor Prostaglandin (PG)E(2) for Treatment of Non Small Cell Lung Cancer

Wednesday, April 11, 2018 4:17
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Arnica may have a therapeutic and potential effect in reduced risk and treatment of non small cell lung cancer, some scientists suggested.

The result of the efficacy was reported by numbers of investigation conduced by several respectable institutes, such as University of Groningen and Center for Cancer Research, Bethesda and published on online medical literature.

Lung cancer is a chronic and medical condition characterized by the irregular and controllable cell growth in the lung tissue.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

According to the University of Groningen in the investigated cytotoxicity of 21 flavonoids and 5 sesquiterpene lactones presented in Arnica species on GLC4, a human small cell lung carcinoma cell line, using the microculture tetrazolium (MTT) assays.

* Application of compound cisplatin (IC50 = 1.1 microM and 2.9 microM showed a greatest inhibition of human small cell lung carcinoma cell line, through cytotoxitic activity in compared to most flavonoids isolated.

* The most toxic compound was the flavone jaceosidin on GLC4

* Helenalin, possessing both the reactive alpha-methylene-gamma-lactone moiety and a reactive alpha,beta-unsubstituted cyclopentenone ring, displayed the strongest cytotoxicity on GLC4.

Flavonoids processed significantly antioxidant and anti-inflammatory activities, according to online literature were found abundantly in tea, citrus fruit, citrus fruit juices, berries, red wine,….

And phytochemicals sesquiterpene lactones found in some herbs, such as Artichoke, Boneset Eupatorium perfoliatum, Burdock, Calea ternifolia, Chamomile,…. are also used for treatment of diseases associated to inflammatory, protozoal, bacterial and microbial infection.

Additionally, in the evaluated the effects of anethole dithiolethione modified valproate, diclofenac and sulindac isolated from Arnica on non-small cell lung cancer (NSCLC) cells, researchers found that injection of the bioactive chemicals exerted a potential anti lung cancer effect through inhibited the levels of prostaglandin (PG)E(2) in NSCLC cell lines A549 and NCI-H1299 in compared to the conventional medicine COX-2 inhibitor DuP-697. 

Prostaglandin (PG)E(2) is linked to progression of several types of cancer through its tumor-associated inflammation in created an immunosuppressive microenvironment, allowing tumor cells to escape immunosurveillance.

Moreover, in compared to all anethole modificatiions in vivo, S-valproate and S-diclofenac, exerted a strong anti growth of A549 cells. but not S-sulindac.

S-valproate and S-diclofenac significantly inhibited A549 or NCI-H1299 xenograft proliferation in nude mice, but had no effect on the nude mouse body weight.

Dr. Moody TW, the lead author, after taking into comparable tests of all ingredients through Western blot, said, “S-valproate and S-diclofenac inhibit the growth of NSCLC cells and reduce PGE(2) levels, they may prove beneficial in the chemoprevention and/or therapy of NSCLC”.  

The information findings suggested that Arnica and its bioctive ingredients may be considered as a functional herb in prevention and combined with conventional standard therapy in stop progression and treatment of non small cell lung cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines by Woerdenbag HJ1, Merfort I, Passreiter CM, Schmidt TJ, Willuhn G, van Uden W, Pras N, Kampinga HH, Konings AW.(PubMed)
(2) Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells by Moody TW1, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA.(PubMed)
(3) A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia by Lam S1, MacAulay C, Le Riche JC, Dyachkova Y, Coldman A, Guillaud M, Hawk E, Christen MO, Gazdar AF.(PubMed)

 

 

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