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Green Tea EGCG Users, Beware of 6 Interactions and 4 Crucial Side Effects, Scientists Revealed

Monday, April 16, 2018 4:30
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Green tea containing highest amount of antioxidants than any drink or food with the same volume, is the leaves of Camellia sinensis, undergone minimal oxidation during processing and originated from China. 

The leaves are precious drinks in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. 

Because of their health benefits, green tea is cultivated for commercial purposes all over the world.

Epigallocatechin(EGCG), including catechins, is a phytochemical of Flavan-3-ols, in the group of Flavonoids (polyphenols), found abundantly in green tea, St John wort, black Tea, carob flour, Fuji apples, etc.

A. Interactions 

1. Oxidation

Risk of oxidation increased with air contact as humidity and temperature may enhance EGCG degradation(12).

2. Optimized Extract Efficacy

In order to optimize the EGCG efficacy, intake the extract at least 30 min before breakfast and dinner(13).

3. Interaction with Hard Waters

Hard Waters containing elevated amounts of calcium, magnesium and other metals may affect the digestive absorption of EGCG(14).

4. Vitamin C

Intake EGCG with vitamin C may improve the extract bioavailability(15).

5. Omega 3 Fatty Acid

Intake EGCG with Omega-3 polyunsaturated fatty acids may enhance the extract bioavailability(16)

6. Piperine

Intake EGCG with Piperine may increase the efficacy of the extract through enhancing digestive absorption(13).

B. Side Effects

1. Anxiety

Intake of EGG may increase risk of anxiety, therefore people who are taking the anxiolytic medicine should avoid to inject EGCG(17).

2. Hypoglycemic Effect

Intake of EGCG may lower blood sugar, therefore people with low blood glucose should avoid to drink green tea and intake of the extract(18).

3. Anemia

EGCG is an iron inhibitor, therefore people with iron deficiency anemia should avoid intake of EGCG(19).

4. Liver and Kidney Toxicity

Over dose of EGCG  may induce toxicity to both liver and kidney(20)


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