Pacifier Biosensor Could Help Monitor Newborn Health

A pacifier biosensor could someday be used to non-invasively monitor glucose in the saliva of infants. 

Credit: Adapted from Analytical Chemistry 2019, DOI: 10.1021/acs.analchem.9b03379

Scientists have previously developed wearable biosensors that are incorporated into clothing or stuck to the skin. However, long-term use of these devices might cause discomfort that infants cannot easily communicate, among other disadvantages. So far, all of the wearable devices made for babies measure only physical characteristics like heart or respiration rate and not biomarkers, such as glucose. 

 

Continuous glucose monitoring in newborns, which is available only in major hospitals, usually requires piercing the infant’s skin to reach interstitial fluid. Joseph Wang, Alberto Escarpa and colleagues wanted to develop a baby-friendly biosensor in the form of a pacifier that could collect saliva and analyze it for biomarkers.

As a proof of concept, the researchers made a pacifier with a nipple that contained a narrow channel. It was designed so that when an infant sucked on the pacifier, small amounts of saliva would be transferred through the channel to a detection chamber. There, an enzyme attached to an electrode strip would convert glucose in the fluid to a weak electrical signal, which could be detected wirelessly by a cell phone app. The strength of the current correlated with the amount of glucose in saliva samples. 

 

The researchers haven’t yet tested the device with babies, but they conducted a preliminary analysis with adult type 1 diabetes patients. Using the pacifier, the team detected changes in glucose concentrations in the patients’ saliva before and after a meal. The device could someday be configured to monitor other disease biomarkers, the researchers say.

Contacts and sources:
Katie CottinghamThe American Chemical Society

Publication: The authors acknowledge funding from the UCSD Center for Wearable Sensors, the TRANSNANOAVANSENS program from the Community of Madrid (Spain) and the Spanish Ministry of Economy and Business, the FPI Fellowship from the University of Alcalá and a CNPq fellowship.

The abstract that accompanies this study is available here.