Molecular hydrogen (H2 gas) has powerful antioxidant and anti-inflammatory effects,(1) making it potentially useful for COVID-19, as explained in this video by Tyler W. LeBaron, founder of the science-based nonprofit Molecular Hydrogen Institute.

This is very positive information as a treatment for COVID-19 spike protiens. This may also offer relief for those people who already took the shot and now regret their decision. 

I found this information over at “One Day MD” Website. 

In his video, LeBaron reviews the pathophysiology of COVID-19 and explains why H2 is being clinically investigated by discussing the proposed mechanisms of how molecular hydrogen might ameliorate this particular disease.

Molecular Hydrogen Institute COVID-19 Pathophysiology & the Rationale for why Molecular Hydrogen is being clinically investigated

In fact, several Chinese investigators are using H2 therapy in COVID-19 patients, (Chinese Clinical Trial Registry,3) and preliminary results (4,5) are encouraging enough that Dr. Zhong Nanshan, the epidemiologist who discovered the SARS virus (SARS-CoV-1) in 2003, is now recommending H2 therapy for COVID-19. (6)

While more research is needed to confirm benefits and beneficial outcomes in COVID-19 cases, the latest COVID-19 treatment guide (7) by the Chinese National Health Commission includes hydrogen inhalation.

LeBaron includes a video clip of Chinese patients given a hydrogen-oxygen inhaler mix, who say it eliminated chest pain and cough, and allowed for deeper breathing without discomfort. That said, LeBaron notes: HNEX™ can be used with a nebulizer, for direct delivery into the lungs. 

Pathophysiology of COVID-19

As explained by LeBaron, the SARS-CoV-2 virus responsible for COVID-19 enters the lungs, where it attacks the type 2 pneumocytes, (8) alveolar cells responsible for the secretion of surfactants that reduce the surface tension of fluids in your lungs and are thus important for elasticity.

The SARS-CoV-2 virus uses a spiked protein to anchor itself to the ACE-2 receptor (9) of the cell. This is how it gains entry and releases its positive-sense single-strand RNA into the cell. By inserting its RNA, the virus essentially hijacks the cell, as it triggers viral replication to occur inside the cell.

In response, macrophages (white blood cells) are activated to combat the infection, and they in turn release a variety of cytokines, including interleukin-6 (Il-6), IL-1 and TNF-alpha, into your blood plasma. Once the cytokines enter your plasma, neutrophils are recruited, thus increasing vasodilation (expansion of your blood vessels) and capillary permeability.

Inside the cell, reactive oxygen species (ROS) are also created in an effort to kill the infected cell and prevent viral replication. This is an essential part of your body’s defense system. However, as the process progresses you end up with increasing amounts of ROS and inflammation. Worse, as the virus continues to attack your type 2 pneumocytes, your lungs cannot work correctly.

As the surface tension of the fluids in your lungs is reduced, your alveoli can no longer maintain the proper gas exchange, and your oxygen requirement goes up. Declining elasticity of the lungs also makes breathing more difficult. Add in high amounts of ROS, and the whole alveoli ends up dying. This is part of what’s causing the cough.

As inflammation and vasodilation progresses, you can end up with low blood pressure, which is why you feel fatigued and weak. Lower blood pressure also causes low blood perfusion, which in turn means your cells will not get the oxygen and nutrients they need for optimal function. It also impairs metabolic waste removal. The low oxygen levels (hypoxia) result in feeling short of breath.

Unless successfully treated, this chain of events leads to cell death, multi-system organ failure (lungs, liver and kidneys), acute respiratory distress (ARD) and, ultimately, death.

Stopping the Destructive Cycle

To save the patient, something needs to be done to stop this destructive cascade of events. How do we inhibit viral replication and boost immune system function? As explained by LeBaron, most of the destruction occurs by ROS and systemic inflammation.

ROS are molecules that cause oxidative damage. However, they’re not all bad all the time. Neutrophils that produce ROS also produce nitric oxide and superoxide, which are crucial. Superoxide helps kill the pathogen, but you also don’t want too much of it, so it needs to be regulated.

Nitric oxide also needs to be regulated. While it can inhibit viral replication and helps boost your immune system, you don’t want too much. As levels of superoxide and nitric oxide rise, they start forming peroxynitrites, which are extremely damaging, which in turn form hydroxyl radicals, the most cytotoxic ROS.

Normally, when superoxide has done its job, it’s converted by superoxide dismutase into hydrogen peroxide, which in turn is converted into water and oxygen.

This process is regulated by a transcription factor called Nrf2/keap1. When this transcription factor is activated, it goes into the cell’s nucleus, where it binds with the antioxidant response element (ARE), which triggers your body’s natural antioxidants such as glutathione and catalase.

As noted by LeBaron, Nrf2 — which is involved in phase 2 detoxification — regulates more than 200 protective proteins and enzymes. The problem is that when ROS is overabundant and out of control, the Nrf2 system is depleted and can no longer regulate the inflammatory process.

Understanding Molecular Hydrogen

Molecular hydrogen or H2 has the ability to activate the Nrf2/keap1 pathway, thereby replenishing your endogenous antioxidants. In so doing, H2 helps regulate and maintain homeostasis in the whole system, preventing the infection from getting out of control and causing cell death.

Hydrogen can also downregulate NOX and NOS enzymes, thus lowering superoxide and nitric oxide production respectively. This is good, as when these two molecules are increased too much they instantly combine to create the pernicious peroxynitrite molecule. H2 also supports your mitochondrial function. Importantly, H2 selectively reduces peroxynitrites and hydroxyl radicals.

This gives H2 a significant advantage over other antioxidants such as vitamin C, which act indiscriminately with superoxide and nitric oxide — both of which also have important and beneficial functions. H2 does not interact with either superoxide or nitric oxide. The only thing H2 can react with are the most dangerous ROS such as peroxynitrites and hydroxyl radicals.(10)

As a result, your superoxide and nitric oxide are left to perform beneficial functions while the H2 eliminates the most dangerous byproducts of superoxide and nitric oxide, while simultaneously increasing your body’s natural production of antioxidants and regulating the enzymes that produce superoxide and nitric oxide. To get a clearer picture in your mind of how H2 steps in to break the destructive chain, see LeBaron’s video.

H2 also steps in to prevent a cytokine storm from occurring. A cytokine storm occurs when the upregulation of cytokines is greater than your body can handle. Cytokines are regulated by transcription factors, and ROS regulate these transcription factors. Inflammatory transcription factors, in turn, create more inflammation, which stimulate more ROS production.

This is a vicious cycle that results in increased cell death, which leads to multiorgan failure, which leads to death. H2 has been shown to regulate these transcription factors in several animal and human studies, thus breaking the vicious cycle. This is what makes H2 so anti-inflammatory. As summarized by LeBaron at the end of his video:

“Hydrogen gas, being a very simple, small molecule, can help to regulate the redox status of the cell by selectively reducing the very bad [ROS], help to regulate and improve the Nrf2/keap1 pathway to maintain our body’s redox homeostasis.

This is in our immune system. We don’t just want to get rid of it. Yes, it is what is killing us, but it is also very important to have, so that we can get better. So, that is the … rationale for [using hydrogen gas] for COVID-19.”

Dosing and Availability

Although the specific clinical studies on COVID-19 are being conducted with H2 inhalation, H2 dissolved in water has been shown to be more effective than inhalation in other animal disease models. (11) Additionally, another article (12) suggests that the H2-infused nitric oxide-producing beverage from H2Bev called HydroShot, should also be clinically investigated for its reported preliminary effects.

However, while there are various ways of getting H2, the simplest and most practical delivery system is molecular hydrogen water. 

Also, the absolute quantity of H2 is far less important than pulsing or creating an acute elevation of H2 in your system over a short period. That acute elevation is what activates the Nrf2 pathway. When exposure is continuous, even if elevated, it has virtually no effect.

Clearly, we need more research to be better able to answer dosing questions, but in the interim, it seems customizing the dose to your personal circumstances would be most appropriate. So, if you’re in normal, non-stressful circumstances at home, not really doing anything very stressful and not exercising much, maybe taking H2 water twice a day is sufficient.

However, if you exercise a lot, you may want to take it two to three times a day to help reduce the oxidative stress from your exercise. Ditto if you’re traveling and exposing yourself to free radical stress from ionizing radiation at 35,000 feet. In such a circumstance, it might be appropriate to take it every two hours while you’re in the air.

Considering their safety, ease of use, and beneficial effects on immune function and health, molecular hydrogen water are a no-brainer solution in my view, and they could be quite helpful for many conditions, including COVID-19, which is why H2 is being clinically investigated.

HNEX™ Molecular hydrogen water was developed with a patented technology that has been scientifically tested and shown to signal the activation of genetic pathways which can lead to positive impacts in the following areas of health.

HNEX™ is the first supplement on the market that contains active hydro-oxygen Nano structured molecules, providing powerful cellular messengers that help protect, rejuvenate and restore cells. 

HNEX™ can be used with a nebulizer, for direct delivery into the lungs.

Don’t wait any longer, the peace of mind you have been searching for is in every bottle of HNEX™ Molecular hydrogen water, order your first bottle today by following this link

Here are many more useful links to peer-reviewed scientific articles on molecular hydrogen, research collaboration and many educational articles on molecular hydrogen.

Improve immune system health

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/30102387/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/160993/
• Scientific Report | 3 https ://pubmed.ncbi.nlm.nih.gov/22460088/
• Scientific Report | 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495244/
• Scientific Report | 5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560203/

Modulate hormone balance to support vitality and wellness

• Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/
• Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178641/
• Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753184/
• Scientific Report | 4 https://pubmed.ncbi.nlm.nih.gov/28669654/
• Scientific Report | 5 https://pubmed.ncbi.nlm.nih.gov/28560519/

Help maintain a healthy inflammatory response antioxidant

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/32189665/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/32699287/
• Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988658/
• Scientific Report | 4 https://pubmed.ncbi.nlm.nih.gov/30127861/
• Scientific Report | 5 https://pubmed.ncbi.nlm.nih.gov/30243702/

Improve gut health and digestive enzyme production

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/22146004/
• Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297538/
• Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/25523462/
• Scientific Report | 4 https://pubmed.ncbi.nlm.nih.gov/23610159/
• Scientific Report | 5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799803/

Help maintain cardiovascular health and support arterial elasticity

• Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395574/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/30486243/
• Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434465/
• Scientific Report | 4 https://pubmed.ncbi.nlm.nih.gov/28474871/
• Scientific Report | 5 https://pubmed.ncbi.nlm.nih.gov/25295663/

Protect the Liver – Research has shown hydrogen water also significantly improved liver function and reduced oxidative stress in patients with chronic hepatitis B.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/24127924/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/23682614%20
• Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/24127924%20

Protect the Heart – In diabetic mice, hydrogen water significantly improved heart health and prevented heart disease. In the future, it could become a nutritional intervention for preventing heart problems in people with diabetes.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/25979689%20

Helps Hearing Loss – Hearing loss often results from oxidative damage (due to aging, noise, or drugs). Molecular hydrogen has been shown to protect the cells responsible for hearing from this damage and increase their survival. In guinea pigs, hydrogen water prevented the death of cells responsible for hearing after noise exposure. This research provides indications that hydrogen water could potentially protect against hearing loss caused by noise or other types of oxidative stress.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/19339905%20
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/22387110%20
• Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/24945316%20

Protect the Eyes – Research has shown hydrogen-loaded eye drops aided the recovery of eye injuries caused by high eye pressure in rats. This protection of the eye nerves resulted from the solution’s antioxidant action. This presents the future possibility that hydrogen solutions could be used as a first-aid eye rinse to prevent blindness from chemical burns.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/19834032/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/20847117%20

Help Combat Allergies – There is a potential benefit for those who suffer allergies when they use hydrogen water, which has been shown to help against allergies due to its antioxidant action. A study has shown the benefits of hydrogen water in balancing the immune response for the common inflammatory allergy condition, Eczema. In mice with eczema, hydrogen water improved symptoms by suppressing inflammation and balancing both Th1 and Th2 responses.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/19766097%20
• Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852999/

Boosts Skin Health – Hydrogen water has been shown to help boost collagen production, reduce UV damage and act as an antioxidant in skin cells. This shows the potential of hydrogen water as a pleasant and safe way to reverse skin aging. The use of hydrogen water improved skin health in patients with skin redness and inflammation/pain.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/22607973/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/22607973/

Diabetes Improvements Worth Knowing – Research has shown that drinking hydrogen water decreased cholesterol, improved glucose tolerance and insulin resistance in a study (DB-RCT) of 36 patients with type 2 diabetes or prediabetes (impaired glucose tolerance). The patients drank 900 mL of hydrogen water daily for 8 weeks. Although it may be a safe way to reduce the risk of type 2 diabetes, drinking sufficient amounts of regular water alone may be helpful enough. Low water intake is linked to an increased risk of high blood sugar.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/19083400%20
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/21994426%20

Boosting Weight Loss – Studies have shown that long-term drinking of hydrogen water helped lose body fat and weight in rats. It boosted burning fats and sugars for energy, without any change in diet. In fact, drinking hydrogen water had similar effects on the body as did calorie restriction.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/21293445%20

Athletic & Muscle Performance – In an experiment with 10 young athletes (DB-CT), drinking hydrogen water reduced lactic acid build-up during heavy exercise and decreased muscle fatigue. Drinking 2 L of hydrogen water daily helped 8 cyclists power through sprints with more energy and less exhaustion in one small 2-week study. In a study on mice with a serious muscle-wasting disease (Duchenne muscular dystrophy), hydrogen water was seen to limit abnormal body mass gain and to increase the production of the antioxidant glutathione peroxidase. Further research will be required to determine if hydrogen water could potentially offer health improvements for muscular dystrophy in DMD patients.

• Scientific Report | 1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395574/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/28474871/
• Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/26866650/

Suppressing Inflammation – In one pilot study, 20 patients with rheumatoid arthritis drank 0.5 L/day of hydrogen water for 4 weeks. By the end of the study, all patients with early rheumatoid arthritis achieved remission and 20% became symptom-free. Molecular hydrogen (H2) also had anti-inflammatory effects in many animal studies.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/23031079/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/23859555/
• Scientific Report | 3 https://pubmed.ncbi.nlm.nih.gov/11510417/

Mood Disorders – Scientific research showed hydrogen water restored the natural growth of brain cells in mice. Since this also happens in people who overcome depression (with antidepressants or otherwise), hydrogen water has the potential for improving depression and other mood disorders.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/18563058/
• Scientific Report | 2 https://pubmed.ncbi.nlm.nih.gov/24478038%20

Antioxidant & Brain-Protective Effects – Infusing molecular hydrogen into water has been shown to act by reducing the most toxic reactive oxygen species (ROS) which protects the cells from damage. A pilot study of 38 stroke patients showed that hydrogen water was safe and had a mild antioxidant effect.

• Scientific Report | 1 https://pubmed.ncbi.nlm.nih.gov/17486089/
• Scientific Report | 2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694409/
• Scientific Report | 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865993/

———————————-

Related Articles:

Fountain of Youth: Now You Can Turn Back the Clock

Advanced Study Reveals Improved Liver Function And Reduce Oxidative Stress In Patients With Chronic Hepatitis B.

Hydrogen Water & Ionized Water w/Silver Particles, Research for You Immune System – 2021 the Year of Alternative Medicine.

Diabetes Improvements Worth Knowing. The Information Contained In This Article Can Help You Improve Your Quality Of Life!

Try HNEX Today By Clicking Here!