Inner Ear Provides Clues to How Humans Spread Globally

Differences within a population greater than between populations

The hearing and balance system in humans, as in all vertebrates, is housed in a cavity system in the base of the skull – the bony labyrinth of the inner ear. The researchers analyzed the labyrinth structures in human populations from southern and northern Africa, Europe, Asia, Australia, and America, including as far south as Patagonia, using computed tomography to obtain high-resolution 3-D data of the bony labyrinth.

The data showed that the shape of the labyrinth varied greatly, with the variation within a population being considerably greater that the variation between populations. “This typically human variation pattern is also known from comparative genetic data. It shows that all humans are very closely related and have their roots in Africa,” explains UZH anthropologist Marcia Ponce de León.

Morphology of the labyrinth correlates with dispersal distance from Africa

The team further discovered that the 3-D shape of the labyrinth contained important information about the global dispersal of humans from the African continent. The further away a population is geographically from South Africa, the more the shape of the labyrinth differs from that of the South African population. Moreover, the labyrinth data confirm the findings from DNA analyses which show that the genetic distance increases in correlation with the geographical distance from Africa.

Conclusions about inner-continental dispersal history can be drawn

The labyrinth data also indicate population movements within the continents. For example, the labyrinth shapes of prehistoric populations on the Sunda Islands (Indonesia) are similar to those of the indigenous people of Papua and Australia, while today’s population mainly migrated from the Malay archipelago. On the other hand, the labyrinth data also reveals that today’s Europeans and Japanese mainly have their roots in the respective local populations of the Neolithic Period.

Incidental genetic changes do not have functional effect

The new results are surprising because it was previously assumed that the shape of the labyrinth was mainly determined by its function. It has now been shown that despite the very high functional requirements for balance and hearing, nature tolerates an astonishingly wide variation in the labyrinth structure. “This is probably due to random changes in the genetic material. Such changes may have few or no functional consequences, but the associated structural changes provide a record of human dispersal and evolution history,” summarizes the paper’s last author Christoph Zollikofer, professor of anthropology at UZH.

Computed tomography data should be acquired before DNA extraction

The compact bone that surrounds the labyrinth is also interesting for paleogenetics as it contains a large amount of DNA. This gives rise to an acute conflict of interests: While computed tomographic investigations are non-invasive, the process of DNA collection damages the labyrinth. “Paleogenetics is a rapidly growing research field and hundreds of labyrinths from archaeological skeleton collections have already been milled to dust without first being documented,” says Christoph Zollikofer. The research team therefore wants to ensure that computed tomographic data is routinely obtained before bones are released for DNA extraction. “These data form an invaluable archive of the history of fossil hominid and modern human populations,” concludes Marcia Ponce de León.

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 Publication: Marcia S. Ponce de León, Toetik Koesbardiati, John David Weissmann, Marco Milella, Carlos S. Reyna-Blanco, Gen Suwa, Osamu Kondo, Anna-Sapfo Malaspinas, Tim D. White, and Christoph P. E. Zollikofer. Human bony labyrinth is an indicator of population history and dispersal from Africa. PNAS. April 2, 2018. Doi: 10.1073/pnas.1717873115