Studies: Cytochrome P450 and failure of infants to metabolize vaccine excipients

Armed with Knowledge

Cytochrome P-450 is the liver’s enzyme system and is responsible for most drug metabolism.  Numerous medications, nutrients, and herbal therapies are metabolized through the cytochrome P450 (CYP450) enzyme system. This system can be inhibited or induced by drugs including excipients in vaccines. It is to be noted that cytochrome P450 is maturing and is immature in infants who are regularly vaccinated as early as one hour and those who receive the Vitamin K injection.

There are more than 50 CYP450 enzymes, but the CYP1A2, CYP2C19, CYP2D6, CYP1A2, CYP3A4, and CYP3A5 enzymes are responsible for metabolizing 45% of drug metabolism. The CYP2D6 (20–30%), the CYP2C9 (10%) and the CYP2E1 and CYP1A2 (5%) complete this enzyme system. Many ingredients in vaccines inhibit Cytochrome P450, therefore the offending agent remains in the body of the infant and act as a poison.  If a medication is taken with an agent that inhibits its metabolism, then the toxin level can rise and result in a harmful or adverse effect.

But it is not only all infants that have immature Cyp 450 superfamiilies.  For example, 10% of Caucasians are Cytochrome P450 2D65 are non-metabolizers (Cyp2D6..the superfamily that metabolizes 20-30% of drugs) their whole life long. 7% of African Americans are poor metabolizers of drugs dependent on CYP2D6.  Due to hereditary genetic variations (not defects) they do not have the activity of Cyp 2D6.

Medical treatments and drug protocols including vaccines should be  implemented within a framework of the patient’s heritage, race, and culture in order to provide effective management modalities. Infants as well as adults should be assessed for their ability to metabolize the ingredients in vaccines.

When in comes to diet,  CYP450 inducers and inhibitors are commonly ingested items such as grapefruit juice and tobacco and herbs such as St. John’s Wort.  In the case of grapefruit juice, there are numerous medications known to interact with grapefruit juice including statins, antiarrhythmic agents, immunosuppressive agents, and calcium channel blockers. Furthermore, the inhibition of the enzyme system seems to be dose dependent; thus, the more a patient drinks, the more the inhibition that occurs. Additionally, the effects can last for several days if grapefruit juice is consumed on a regular basis. Luckily, the effect of this is not seen with other citrus juices.

Hopefully, this brief review has opened the door to your inquisitive nature on how the liver’s enzyme system is effected by numerous medications and vaccine excipients and why some patients experience clinically significant unanticipated adverse reactions or therapeutic failures.

CDC VACCINE EXCIPIENTS LIST PER VACCINE  CDC Vaccine excipients-table-2

Effects of Polysorbate 80, a widely used ingredient in vaccines

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism and might have the potential to modify the pharmacokinetics of co-administered drugs, which are substrates of CYP, and thereby enhance their bioavailability.

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