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The Genetic Basis of Bats’ Superpowers Revealed Including Virus Protection

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For the first time, the raw genetic material that codes for bats’ unique adaptations and superpowers such as the ability to fly, to use sound to move effortlessly in complete darkness, to survive and tolerate deadly diseases, to resist ageing and cancer – has been fully revealed by an international research team including scientists at Bristol. The findings are published in Nature.


Credit: University of Bristol,  Nature

In order to uncover bats’ unique traits, the Bat1K consortium led by researchers at University College Dublin, the Max Planck Institutes of Molecular Cell Biology and Genetics (Dresden), and the Max Planck Institute for Psycholinguistics (Nijmegen), generated and analysed six highly accurate bat genomes that are ten times more complete than any bat genome published to date.

To generate these exquisite bat genomes, the team used the newest technologies to sequence the bats’ DNA, and generated new methods to assemble these pieces into the correct order and to identify the genes present.

Emma Teeling, University College Dublin, Co-Founding Director of Bat1K and Senior Author, said: “Given these exquisite bat genomes, we can now better understand how bats tolerate viruses, slow down ageing, and have evolved flight and echolocation. These genomes are the tools needed to identify the genetic solutions evolved in bats that ultimately could be harnessed to alleviate human ageing and disease.”

Eugene Myers, Director of Max Planck Institute of Molecular Cell Biology and Genetics, and the Center for Systems Biology, Dresden, Germany, and the study’s Senior Author, added: “Using the latest DNA sequencing technologies and new computing methods for such data, we have 96-99 per cent of each bat genome in chromosome level reconstructions – an unprecedented quality akin to for example the current human genome reference which is the result of over a decade of intensive “finishing” efforts. As such, these bat genomes provide a superb foundation for experimentation and evolutionary studies of bats’ fascinating abilities and physiological properties.”

The team compared these bat genomes against 42 other mammals to address the unresolved question of where bats are located within the mammalian tree of life. Using novel phylogenetic methods and comprehensive molecular data sets, the team found the strongest support for bats being most closely related to a group called Ferreuungulata that consists of carnivores (which includes dogs, cats and seals, among other species), pangolins, whales and ungulates (hooved mammals).

Greater Horseshoe bat 
Credit: Daniel Whitby

To uncover genomic changes that contribute to the unique adaptations found in bats, the team systematically searched for gene differences between bats and other mammals, identifying regions of the genome that have evolved differently in bats and the loss and gain of genes that may drive bats’ unique traits.

Michael Hiller, Max Planck Research Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Max Planck Institute for the Physics of Complex Systems, and the Center for Systems Biology, Dresden, Senior Author, added: “Our genome scans revealed changes in hearing genes that may contribute to echolocation, which bats use to hunt and navigate in complete darkness. Furthermore, we found expansions of anti-viral genes, unique selection on immune genes, and loss of genes involved in inflammation in bats. These changes may contribute to bats’ exceptional immunity and points to their tolerance of coronaviruses.”

The team also found evidence that bats’ ability to tolerate viruses is reflected in their genomes. The exquisite genomes revealed “fossilised viruses”, evidence of surviving past viral infections, and showed that bat genomes contained a higher diversity than other species providing a genomic record of historical tolerance to viral infection.

Professor Gareth Jones from Bristol’s School of Biological Sciences, who contributed to the study, said: “It has been 20 years since the first human genome was sequenced, and today we can obtain almost complete gene annotations for the genomes of wild mammals to better understand their adaptations and evolution. Analysis of the genomes helped resolve the phylogenetic position of bats in the mammal tree (basal in a lineage that includes carnivores, pangolins, hoofed mammals, pangolins and cetaceans), and supported the hypothesis that laryngeal echolocation is an ancestral trait in all bats. Moreover, the bat genomes revealed the incorporation of diverse ‘fossilised’ viral genomes and selection on immunity-related genes that may contribute to bats’ exceptional immunity.

“One of the genomes we have been studying, to help us understand ageing in bats is from the greater horseshoe bat, which have exceptional longevity for their body size. For example, a six gram Brandt’s bat can live for around 41 years. We plan to now use the genome to investigate epigenetic changes during ageing, and how these changes cause some animals to age biologically faster than expected for their chronological ages.”

Given the quality of the bat genomes the team uniquely identified and experimentally validated several non-coding regulatory regions that may govern bats’ key evolutionary innovations.

Sonja Vernes, Co-Founding Director Bat 1K, Max Planck Institute for Psycholinguistics, Nijmegen, Senior Author, said: “Having such complete genomes allowed us to identify regulatory regions that control gene expression that are unique to bats. Importantly we were able to validate unique bat microRNAs in the lab to show their consequences for gene regulation. In the future we can use these genomes to understand how regulatory regions and epigenomics contributed to the extraordinary adaptations we see in bats.”

This is just a beginning. The remaining ~1,400 living bat species exhibit an incredible diversity in ecology, longevity, sensory perception and immunology, and numerous questions still remain regarding the genomic basis of these spectacular features. Bat1K will answer these questions as more and more exquisite bat genomes are sequenced, further uncovering the genetic basis of bats’ rare and wonderful superpowers.

The study was funded in part by the Max Planck Society, the European Research Council, the Irish Research Council, the Human Frontier Science Program, and the United States National Science Foundation.

Paper: ’Six reference-quality genomes reveal evolution of bat adaptations‘ by Jebb et al. is published in Nature.

 

Contacts and sources:
University of Bristol

 



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