Dodgy cancer research
If you give money to a cancer research charity, how much of it is likely to fund useful and reproducible research? Not much is my conclusion after reading this article in PSI.
The U.S. government spends $5 billion every year on cancer research; charities and private firms add billions more. Yet the return on this investment—in terms of lives saved, suffering reduced—has long been disappointing: Cancer death rates are drifting downward in the past 20 years, but not as quickly as we’d hoped. Even as the science makes incremental progress, it feels as though we’re going in a circle…
…The deeper problem is that much of cancer research in the lab—maybe even most of it—simply can’t be trusted. The data are corrupt. The findings are unstable. The science doesn’t work.
…In other words, we face a replication crisis in the field of biomedicine, not unlike the one we’ve seen in psychology but with far more dire implications. Sloppy data analysis, contaminated lab materials, and poor experimental design all contribute to the problem…
…Begley blames these failures on some systematic problems in the literature, not just in cancer research but all of biomedicine. He says that preclinical work—the basic science often done by government-funded, academic scientists—tends to be quite slipshod. Investigators fail to use controls; or they don’t blind themselves to study groups; or they selectively report their data; or they skip important steps, such as testing their reagents.
Source: http://akhaart.blogspot.com/2016/05/dodgy-cancer-research.html
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