Read the story here. Advertise at Before It's News here.
Profile image
By ProactiveInvestors (Reporter)
Contributor profile | More stories
Story Views
Last Hour:
Last 24 Hours:

Which COVID-19 vaccines are in phase III? A look at Moderna Therapeutics and the chasing pack

% of readers think this story is Fact. Add your two cents.

Moderna Therapeutics (NASDAQ:MRNA) became the first company to take a COVID-19 vaccine into a phase III clinical trial, which will test how safe and effective the inoculation is.

Enrolment of the 30,000 people taking part in the clinical assessment is expected to be completed later this month with results slated for as early as October.

Here we look at the approach taken by the Boston-based biotech and how it differs from the methods deployed by the chasing pack.

Traditional approach

Traditionally, vaccines are made of an inactivated virus, or recombinant proteins that stimulate the immune response.

By providing the body’s defence mechanisms with advanced warning of the virus, they trigger production of the antibodies required to fight real thing when it is contracted.

Moderna’s drug uses different tactics. Driving the process is messenger RNA, or mRNA, which plays a fundamental role in human biology, transferring the instructions stored in DNA to make the proteins required in every living cell.

mRNA medicines are used to instruct a patient’s own cells to produce proteins that could prevent, treat, or cure disease.

Small problem

There’s only one problem — no mRNA drug has ever been approved for human use.

Tal Zaks, the chief medical officer of Moderna, recently explained to Stephen Dubner on the Freakonomics Radio podcast just how and why his team might succeed where it and others have thus far failed.

“I think what we have done uniquely is leverage a decade of engineering and science on top of medicine to sort of break the riddle of how to get an mRNA to make enough protein,” he said.

“And the second element is, we already have proven time and again that we can generate neutralising antibodies with this vaccine.

“So, the question ahead of us is not whether mRNA will work, the question ahead of us is whether neutralising antibodies are going to prevent Covid-19. And I think the likelihood of that answer is very, very high.”

Chasing pack

Not far behind Moderna is another mRNA drug; this one has been developed by Pfizer Inc (NYSE:PFE) and its German partner BioNTech (NASDAQ:BNTX).

There are other vaccine candidates in phase III now that use a DNA mechanism. The charge is being led by Oxford University and the Anglo-Swedish firm AstraZeneca (LON:AZN).

Hard on AZ’s heels is the Chinese firm CanSino Biologics, while Johnson & Johnson (NYSE:JNJ) said its phase III clinical assessment will begin this month, enrolling 60,000 participants.

Among those going the conventional route of using an inactivated virus are Merck & Co Inc (NYSE:MRK) and Sinovac Biotech.

GlaxoSmithKline (LON:GSK) and its partner Vir Biotechnology Inc (NASDAQ:VIR) are developing an antibody-based treatment, as are Eli Lily & Co (NYSE:LLY) and partners Regeneron Pharmaceuticals Inc (NASDAQ:REGN) and Roche Holding AG (SWX:RO).

Story by ProactiveInvestors


Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Please Help Support BeforeitsNews by trying our Natural Health Products below!

Order by Phone at 888-809-8385 or online at

Order by Phone at 888-809-8385 or online at

Get our Free Ebook, "Suppressed Health Secrets"  with  Natural Cures THEY don't want you to know!

Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!

Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.

MitoCopper - Bioavailable Copper destroys pathogens and gives you more energy. (See Blood Video)
Oxy Powder - Natural Colon Cleanser!  Cleans out toxic buildup with oxygen! 
Organic Hemp Extract (CBD) - Full Spectrum high CBD (3300mg) hemp extract eases stiff joints, relieves stress and more!
Nascent Iodine - Promotes detoxification, mental focus and thyroid health.
Smart Meter Cover -  Reduces Smart Meter radiation by 96%!  (See Video)

Immusist Beverage Concentrate - Proprietary blend, formulated to reduce inflammation while hydrating and oxygenating the cells.

Report abuse


Your Comments
Question   Razz  Sad   Evil  Exclaim  Smile  Redface  Biggrin  Surprised  Eek   Confused   Cool  LOL   Mad   Twisted  Rolleyes   Wink  Idea  Arrow  Neutral  Cry   Mr. Green

Load more ...




Email this story
Email this story

If you really want to ban this commenter, please write down the reason:

If you really want to disable all recommended stories, click on OK button. After that, you will be redirect to your options page.