Stroke Risk Nearly Doubles with Standard Ibuprofen Dose: No one wanted to kill the NSAID cash cow, so millions of people have suffered from strokes.
NSAID (nonsteroidal anti-inflammatory drugs) use is closely associated with increased risk of strokes, nearly doubling for ibuprofen doses of more than 200 milligrams, which is the standard amount found in a single over the counter pill. The study, presented at the 2010 Congress of the European Society of Cardiology, documented that even low-dose usage of NSAIDs increased the risk of strokes by 28-86%, depending on the particular drug.(1)
Not a Surprise
The first NSAID was ibuprofen, which was approved by the FDA in 1974. It was known to increase blood flow to the brain after strokes by 1987(2) It should have been expected that effects on strokes would be found, but it’s only now—23 years later—that a definitive study has been done to address that concern.
The Study
The study addressed the entire population of Denmark over age ten, eliminated anyone who’d been in a hospital during the previous five years and anyone taking chronic medications for two years or more. The rest of the population, about half a million people, according to theHeart.org,(2) or a million people, according to MedConnect.com(3), were included. The study was a review of these people from 1997-2005. All NSAIDs, except aspirin and low-dose ibuprofren, are available only by prescription in Denmark.
In January 1997, the median age of the subjects was 39 and 58% were male. During the nine year course of the study, 17% filled one prescription for NSAIDs, 14% filled two or three, and 14% filled four or more. 55% filled no prescriptions for NSAIDs. The average length of use was between 13 days (for rofecoxib) and 24 days (for naproxen).
The risk of stroke increased with amount of NSAID use. theHeart.org reported the following increased risks of stroke:
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