Wheat Gluten Newly Confirmed To Promote Weight Gain
New research confirms some of the basic tenets of the Wheat Belly, a book by Dr. William Davis, which argues that wheat avoidance results in healthy weight loss.
Published in Journal of Nutritional Biochemistry this month, and titled “Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression,” researchers compared the effects of a gluten-based diet to a gluten-free diet in mice.
Researchers Noted
Gluten exclusion (protein complex present in many cereals) has been proposed as an option for the prevention of diseases other than coeliac disease. However, the effects of gluten-free diets on obesity and its mechanisms of action have not been studied. Thus, our objective was to assess whether gluten exclusion can prevent adipose tissue expansion and its consequences.
Mice were fed either a high-fat diet containing 4.5% gluten (Control) or no gluten (GF). The researchers then assessed the following 16 parameters in both groups:
- Body weight
- Adiposity gains
- Leukocyte rolling and adhesion
- Macrophage infiltration
- Cytokine production in adipose tissue
- Blood lipid profiles
- Glycaemia (blood sugar)
- Insulin resistance
- Adipokines
- Expression of PPAR-α and γ
- Lipoprotein lipase (LPL)
- Hormone sensitive lipase (HSL)
- Carnitine palmitoyl acyltransferase-1 (CPT-1)
- Insulin receptor
- GLUT-4
- Adipokines in epidymdimal fat
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2013-01-13 18:48:54
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