Early-life stress-induced anxiety-related behavior

Home of Kyle J. Norton for The Better of Living & Living Health Adrenocorticotropic hormone (ACTH) or corticotropin, is a  hormone produced by the anterior pituitary gland in response to biological stress by effecting the increased production and release of corticosteroids(a)
Early-life stress-induced anxiety-related behavior in adult mice 
Early-life stress may lead to persistent changes in central corticotropin-releasing hormone (CRH) and the CRH receptor 1 (CRHR1) system that modulates anxiety-related behavior. In the study used conditional forebrain CRHR1 knockout (CRHR1-CKO) mice and examined the potential role of forebrain CRHR1 in the anxiogenic effects of early-life stress, indicated that as adults, wild-type mice that received unstable maternal care during the first postnatal week showed reduced body weight gain and increased anxiety levels in the open field test, which were prevented in stressed CRHR1-CKO mice. In the light-dark box test, control CRHR1-CKO mice were less anxious, but early-life stress increased anxiety levels in both wild-type and CRHR1-CKO mice. In the elevated plus maze test, early-life stress had only subtle effects on anxiety-related behavior. Moreover, early-life stress did not alter the basal home cage activity and gene expression levels of key hypothalamic-pituitary-adrenal axis regulators in adult wild-type and CRHR1-CKO mice, but enhanced neuroendocrine reactivity to acute immobilization stress in CRHR1-CKO mice(3).
Chinese Secrets to Fatty Liver and Obesity Reversal
Research based & Scientifically proven Efficacy To Treat Fatty Liver Diseases & Achieve Optimal Health & Loose Weight Recommended by Kyle J. Norton

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For the world most healthy foods lists, visit http://healthy-foods-index.blogspot.com/2011/03/healthy-foods-list.html
For other health articles, please visit http://medicaladvisorjournals.blogspot.ca     
Sources
(a) http://en.wikipedia.org/wiki/Adrenocorticotropic_hormone  
(3) http://www.ncbi.nlm.nih.gov/pubmed/22672268 http://medicaladvisorjournals.blogspot.com