Intravenous Magnesium for Chronic Complex Regional Pain Syndrome Type 1 (CRPS-1)
Home of Kyle J. Norton for The Better of Living & Living Health Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functioning enzymes(a).
Intravenous Magnesium for Chronic Complex Regional Pain Syndrome Type 1 (CRPS-1)
In a randomized double-blind placebo-controlled trial to assess the effects of intravenous administration of magnesium on complex regional pain syndrome type 1 (CRPS-1), showed that no significant differences were found between MgSO4 and placebo on the BOX-11 and ISS at different time points during the trial on intention-to-treat and per-protocol analysis. A significant improvement on the BOX-11 was found after the first week of the trial in both groups (mean 0.7; standard deviation 1.1). For the MgSO4 group, a clinically relevant and statistically significant improvement on the ISS at 1 week (median 5, interquartile range [IQR] -1 to 8) and a significant improvement on the McGill up to 6 weeks (median 2 words, IQR 0-4.5) were found compared with baseline, which were not found in the placebo group. Significant improvement in perceived job participation was found for the MgSO4 group at 12 weeks (median improvement 1.44-1.17; P = 0.01). ISS improved significantly more in patients with a low Hospital Anxiety and Depression Scale (HADS) score (≤10) in the MgSO4 group (mean 4.4 vs mean -3.1; P = 0.02)(5).
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Sources
(a) http://en.wikipedia.org/wiki/Magnesium
(5) http://www.ncbi.nlm.nih.gov/pubmed/23889940 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/intravenous-magnesium-for-chronic.html
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