Obesity, leptin, and Alzheimer's disease
Home of Kyle J. Norton for The Better of Living & Living Health Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese. Clinically Overweight and obesity are defined indicators of a disease process characterized by the accumulation of body fat due to an excess of energy intake (nutritional intake) relative to energy expenditure (physical activity)(a).
Obesity, leptin, and Alzheimer‘s disease
Obesity has various deleterious effects on health largely associated with metabolic abnormalities including abnormal glucose and lipid homeostasis that are associated with vascular injury and known cardiac, renal, and cerebrovascular complications. According to the study by the University of Pennsylvania, advanced age is also associated with increased adiposity, decreased lean mass, and increased risk for obesity-related diseases. Although many of these obesity- and age-related disease processes have long been subsumed to be secondary to metabolic or vascular dysfunction, increasing evidence indicates that obesity also modulates nonvascular diseases such as Alzheimer‘s disease (AD) dementia. The link between peripheral obesity and neurodegeneration will be explored, using adipokines and AD as a template(3).
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Sources
(3) http://www.ncbi.nlm.nih.gov/pubmed/22211890 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/obesity-leptin-and-alzheimers-disease.html
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