The Holistic approach for Prevention, controlling and Treatment - Chinese Herbs for restoring balance of the body after treatment of Candida Albicans Overgrowth

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By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth result in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

                                                           Treatment

                                                In Traditional Chinese Medicine 

In traditional Chinese medicine, candidiasis is defined as a malfunction of the Triple Burner-related condition due to spleen and stomach disorder(401), causing excess fluid or phlegm in our system(402), weakening immune system(403)(402), leading to damp heat accumulates in the Lower, Middle and Upper Burner causes of candidiasis(401).

                                                   Cleansing TCM Herbs

Overgrowth of candida in TCM is considered as the accumulation of waste, phlegm and damp heat, toxins due to inability of spleen and stomach in digesting foods properly(401).

Chinese herbs for Upper and Middle burner disorder causes of Candida albicans overgrowth

1. Huang Lian (Rhizoma Coptidis)
Huang lian is aslo known as Canker roots, a genus of Coptis in the family Ranunculaceae, native to Asia and North America. The bitter and cool herb has been used in TCM as anti microbial(462)(463)(464)Including Candica albicans(465)(466), anti inflammatory(467)(468), antidiabetic(469)(470), anti palette coagulative(461) agents and to treat irritable bowel syndrome(471), inflammation of intestine and diarrhea(460) caused by bacterial infection by clearing heat(460)(461), drying damp(460)(461), dispersing fire and expelling toxins(460) as it promotes the functions of heart, large intestine, liver, and stomach channels(461).

2. Da Huang (Radix et Rhizoma Rhei)
Da Huang is also known as Ruhbarb, is a genus Rheum, belonging the family Polygonaceae. The bitter and cold herb has been used in TCM to treat diarrhoea(472), bowel movement(473), aging induced dementia(474), tumor(475), abdominal-distention and/or pain(476), hemorrhoidal bleeding(476) and urination burning sensation(476), bacterial infection(477) and improve blood circulation(477), by clearing damp heat(477), expelling toxins(478)(480) and invigorating blood(477) as it promotes the functions of heart, large intestine, liver, stomach channels(476). According to Advances in Viridans Streptococci Research and Treatment: 2011 Edition, da huang showed to exhibit antimicrobial activity against many strains of bacterias(479), including candida albicans(480).

3. Huang Bai (Cortex Phellodendri) 
Huang Bai is also known as Cork-tree, a genus of Phellodendra, belonging to the family Rutaceae, native to east and northeast Asia. The bitter and cold herb has been used in TCM as anti microbial(481)(482)(483), including candida albicans(484)(485), anti inflammatory(486)(487)  and anti trichomoniasis(488), to lower blood pressure(489) and blood sugar(490) by
clearing damp heat(481) in the lower burner due to bacterial infection(480), dispersing fire(480) and expeling toxins(480) as it promotes the functions of kidney and bladder channels(488).

4. Shi Gao (Herba Achilleae alpinae)
Shi Gao is also known as Gypsum, a very soft mineral composed of calcium sulfate dihydrate. The bitter, very cod and acrid herb has been used in TCM as antipyretics(492), antimicrobial(496)(497) including candida albicans(498)and to treat asthma(492), relieve pain(493)(494) and diabetes(495) by clearing and fire(499), as it promotes the functions of lung, kidney channels(500).

5. Lian Qiao (Fructus Forsythiae Suspensae)
Lian Qiao is also known as Forsythia fruit, is a genus of Forsythia, belongs to the family Oleaceae, native to Eastern Asia. The bitter, cold and slightly acrid herb has been used as spectrum antibiotic(501)(502)(503), antioxidant(502)(503), inflammatory(504)(505) agents and to  treat asthma(506), lower fever(507), cholesterol(509) and to protect liver(510) by clearing heat and toxins, and resolving abscesses as it promotes the functions of heart, liver and gallbladder channels(508).

6. Ju Hua (Flos Chrysanthemi Morifolii)
Ju Hua also known as chrysanthemum flower, a genus of chrysanthemum, belongs to the family Asteraceae, native to Asia and northeastern Europe. The sweet, bitter and slightly cold herb has been used in TCM as anti-inflammatory(511)(512)(513), antibiotic(514)(515), including andida albicans(519), analgesic(516) and antipyretic(517) agents and to benefit diabetes(518) by expelling wind, clearing heat and toxins as it promotes the functions of lung and liver channels(517).

7. Bo He (Herba Menthae Haplocalycis)
Bo he is also known as Mint, a genus of Mentha, belonging to the family Lamiaceae, native to the through the world. The acrid and cold herb has been used in TCM as anti-pyretic(520), antinociceptive(520)(521), antimicrobial(522)(523) including candida albicans(524)(525), antioxidant(522)(523) anti-inflammatory(526)(527) agents and to treat wind-heat(528) cause of infection(522)(523) by dispersing wind-heat(528) and clearing fire(528) as it promotes the functions of liver and lung channels(529).

8. Gan Cao (Radix Glycyrrhizae Uralensis)
Gan Cao is also known as Licorice, a genus of Glycyrrhiza, belonging to the family Fabaceae, native to southern Europe and parts of Asia. The sweet herb has been used in TCM as anti microbial(530)(531)(532), including candida akbicans(533)(534), antioxidant(530)(531), inflammatory(536)(537), and anti allergic(538)(539)(540) agents by tonifying spleen, benefiting qi, moistening lung as it promotes all 12 channels(535).

9. Etc.

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+ References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V¹, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN¹, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3)  Multidrug resistance in yeast Candida by Prasad R¹, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ¹, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D¹, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N¹, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH¹, Melake NA², Somily AM³, Zakaria AS⁴, Baddour MM⁵, Mahmoud AZ⁶(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H¹, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J¹.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H¹, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(401) Traditional Chinese Medicine for Candidiasis(Traditional Chinese medicine information page)
(460) Huang Lian(Rhizoma Coptidis)
(461) Huang Lian(Complementary and Alternative Healing University)
(462) Study of the anti-MRSA activity of Rhizoma coptidis by chemical fingerprinting and broth microdilution methods by Luo JY¹, Yan D², Yang MH³.(PubMed)
(463) Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method by Chen Y¹, Li Y, Wang Y, Yang Q, Dong Y, Weng X, Zhu X, Wang Y, Gong Z, Zhang R.(PubMed)
(464) Evaluation of antibacterial effect and mode of Coptidis rhizoma by microcalorimetry coupled with chemometric techniques by Kong W¹, Wang J, Xiao X, Chen S, Yang M.(PubMed)
(465) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ¹, Wong RW, Samaranayake LP.(PubMed)
(466) Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS by Liu X¹, Han Y, Peng K, Liu Y, Li J, Liu H.(PubMed)
(467) Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods by Li JY¹, Wang XB¹, Luo JG¹, Kong LY².(PubMed)
(468)Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6 by Iizuka N¹, Miyamoto K, Hazama S, Yoshino S, Yoshimura K, Okita K, Fukumoto T, Yamamoto S, Tangoku A, Oka M.(PubMed)
(469)The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research by Wang H¹, Mu W¹, Shang H¹, Lin J¹, Lei X¹.(PubMed)
(470) [Effects of alkaloids from coptidis rhizoma on blood lipid metabolism and low-denstity lipoprotein receptor mRNA in golden hamsters].[Article in Chinese] by Wu H, Wang YZ, Wang DZ, Pang J, Ye XL, Li XG.(PubMed)
(471) Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats by Zipeng Gong,1 Ying Chen,1 Ruijie Zhang,1 Yinghan Wang,1,2 Qing Yang,1 Yan Guo,1 Xiaogang Weng,1 Shuangrong Gao,1 Hailin Wang,1 Xiaoxin Zhu,1 Yu Dong,3 Yujie Li,1 and Yajie Wang1(Hindawi Publishing Corporation)
(472) Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model by Liu C¹, Zheng Y², Xu W², Wang H², Lin N¹.(PubMed)
(473) [Effects of Na-FA on gastrointestinal movement and gastric ulcer in mice].[Article in Chinese] by Li YM¹, Li BC, Li P, Liu JZ, Cui JL, Mei ZQ.(PubMed)
(474) A clinical study on compound da huang (radix et Rhizoma rhei) preparations for improvement of senile persons’ memory ability by Tian J¹, Du H, Yang H, Liu X, Li Z.(PubMed)
(475) Inhibitory effect of Daesungki-Tang on the invasiveness potential of hepatocellular carcinoma through inhibition of matrix metalloproteinase-2 and -9 activities by Ha KT¹, Kim JK, Lee YC, Kim CH.(PubMed)
(476) Da Huang(Complementary and Alternative Healing University)
(477) A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis by Zhang L¹, Yang L, Zheng X.(PubMed)
(478) The Treatment of Modern Western Medical Diseases with Chinese Medicine: A …By Bob Flaws, Philippe Sionneau. Page 131
(479) Advances in Viridans Streptococci Research and Treatment: 2011 Edition
(480) A Handbook of TCM Pediatrics: A Practitioner’s Guide to the Care and …By Bob Flaws. Page 101
(481) Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus by Yu HH¹, Kim KJ, Cha JD, Kim HK, Lee YE, Choi NY, You YO.(PubMed)
(482) Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study by Wong RW¹, Hägg U, Samaranayake L, Yuen MK, Seneviratne CJ, Kao R.(PubMed)
(483) [Study on the Chinese herbal formula for treatment of vaginitis and the antimicrobial activity in murine models].[Article in Chinese] by Fu TT¹, Wu JY, Wang L, Ma Y, Wang Y, Liu Y, Ding H.(PubMed)

(484) Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS by Liu X¹, Han Y, Peng K, Liu Y, Li J, Liu H.(PubMed)

(491) [Observation of the curative effect of qingchang huashi recipe for treating active ulcerative colitis of inner-accumulation of damp-heat syndrome].[Article in Chinese] by He HH¹, Shen H, Zheng K.(PubMed)
(492) Antipyretic and anti-asthmatic activities of traditional Chinese herb-pairs, Ephedra and Gypsum by Mei F¹, Xing XF, Tang QF, Chen FL, Guo Y, Song S, Tan XM, Luo JB.(PubMed)
(493) Treatment of painful Modic type I changes by vertebral augmentation with bioactive resorbable bone cement by Masala S¹, Anselmetti GC, Marcia S, Nano G, Taglieri A, Calabria E, Chiocchi M, Simonetti G.(PubMed)
(494) A comparative study with oral nifedipine, intravenous nimodipine, and magnesium sulfate in postoperative analgesia by Zarauza R¹, Sáez-Fernández AN, Iribarren MJ, Carrascosa F, Adame M, Fidalgo I, Monedero P.(PubMed)
(495) Scorpion in Combination with Gypsum: Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions by Xie W¹, Zhao Y, Gu D, Du L, Cai G, Zhang Y.(PubMed)
(496) Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections by Howlin RP¹, Brayford MJ², Webb JS¹, Cooper JJ², Aiken SS², Stoodley P³.(PubMed)
(497) Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites by McConoughey SJ¹, Howlin RP, Wiseman J, Stoodley P, Calhoun JH.(PubMed)
(498) In Vitro Activity of Calcium Sulfate and Hydroxyapatite Antifungal Disks Loaded with Amphotericin B or Voriconazole in Consideration for Adjunctive Osteomyelitis Management by Karr JC¹, Lauretta J.(PubMed)
(499) Herbs that c;ear heat(Chapter 3)
(500) Shi Gao (Complementary and Alternative Healing University)
(501) Chemical constituents from the fruits of Forsythia suspensa and their antimicrobial activity by Kuo PC1, Chen GF2, Yang ML3, Lin YH1, Peng CC1.(PubMed)
(502) Isoforsythiaside, an antioxidant and antibacterial phenylethanoid glycoside isolated from Forsythia suspensa by Qu H1, Zhang Y, Chai X, Sun W.(PubMed)
(503) Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa by Qu H1, Zhang Y, Wang Y, Li B, Sun W.(PubMed)
(504) Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production by Pan X1, Cao X, Li N, Xu Y, Wu Q, Bai J, Yin Z, Luo L, Lan L.(PubMed)
(505) New alkaloids from Forsythia suspensa and their anti-inflammatory activities by Dai SJ1, Ren Y, Shen L, Zhang DW.(PubMed)
(506) Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs by Lee JH1, Lee JY, Kim TD, Kim CJ.(PubMed)
(507) A strategy for evaluating antipyretic efficacy of Chinese herbal medicines based on UV spectra fingerprints by Ni LJ1, Zhang LG, Hou J, Shi WZ, Guo ML.(PubMed)
(508) Lian qiao (Complementary and Alternative Healing University)
(509) Effects of forsythia fruit extracts and lignan on lipid metabolism by Cho SH1, Rhee SJ, Choi SW, Choi Y.(PubMed)
(510) Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Lu T1, Piao XL, Zhang Q, Wang D, Piao XS, Kim SW.(PubMed)
(511) Anti-inflammatory components of Chrysanthemum indicum flowers by Luyen BT1, Tai BH2, Thao NP2, Cha JY3, Lee HY3, Lee YM4, Kim YH5.(PubMed)
(512) Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages by Cheon MS1, Yoon T, Lee do Y, Choi G, Moon BC, Lee AY, Choo BK, Kim HK.(PubMed)
(513) Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production by Pyee Y1, Chung HJ, Choi TJ, Park HJ, Hong JY, Kim JS, Kang SS, Lee SK.(PubMed)
(514) Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L and its antibacterial and cytotoxic effects: an in vitro study by  Arokiyaraj S1, Arasu MV2, Vincent S3, Prakash NU4, Choi SH5, Oh YK1, Choi KC2, Kim KH6.(PubMed)
(515) Composition and antibacterial activity of essential oils from leaf, stem and root of Chrysanthemum parthenium (L.) Bernh. from Iran by Shafaghat A1, Sadeghi H, Oji K.(PubMed)
(516) Analgesic activity of the aqueous fraction from the ethanolic extract of Chrysanthemum indicum in mice by Chen YF1, Zhao MH, Yan M, Shi GB, Hou GX, Huang Y, Wang X, Zhao QC.(PubMed)
(517) Ju hua (Complementary and Alternative Healing University)
(518) Chrysanthemum Promotes Adipocyte Differentiation, Adiponectin Secretion and Glucose Uptake by Yamamoto J1, Yamane T, Oishi Y, Shimizu M, Tadaishi M, Kobayashi-Hattori K.(PubMed)
(519) The chemical constituents of endophytic fungus Trichoderma sp. MFF-1 by Li GH1, Wang XB, Liu FF, Dang LZ, Li L, Yang ZS, Xin X, Zhang KQ.(PubMed)
(520) Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice by Amabeoku GJ1, Erasmus SJ, Ojewole JA, Mukinda JT.(PubMed)
(521) Antinociceptive activity of Mentha piperita leaf aqueous extract in mice by Taher YA1.(PubMed)
(522) Antimicrobial and antioxidant activities of three Mentha species essential oils. Mimica-Dukić N1, Bozin B, Soković M, Mihajlović B, Matavulj M.(PubMed)
(523) Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils by Mkaddem M1, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, Romdhane M.(PubMed)
(524) Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans by Stringaro A1, Vavala E2, Colone M1, Pepi F3, Mignogna G4, Garzoli S3, Cecchetti S5, Ragno R3, Angiolella L2.(PubMed)
(525) Anti-Candida activity of Mentha arvensis and Turnera ulmifolia by Santos KK1, Matias EF, Souza CE, Tintino SR, Braga MF, Guedes GM, Nogueira LF, Morais EC, Costa JG, Menezes IR, Coutinho HD.(PubMed)
(526) Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China by Sun Z1, Wang H2, Wang J3, Zhou L3, Yang P1.(PubMed)
(527) Anti-inflammatory effect of Mentha longifolia in lipopolysaccharide-stimulated macrophages: reduction of nitric oxide production through inhibition of inducible nitric oxide synthas by Karimian P1, Kavoosi G, Amirghofran Z.(PubMed)
(528) Pocket Atlas of Chinese Medicine By Marnae C. Ergil, page 269
(529) Bo he(Complementary and Alternative Healing University)
(530) Identification of antimicrobial and antioxidant constituents from licorice of Russian and Xinjiang origin by Okada K, Tamura Y, Yamamoto M, Inoue Y, Takagaki R, Takahashi K, Demizu S, Kajiyama K, Hiraga Y, Kinoshita T.(PubMed)
(531) Antioxidant and antimicrobial constituents of licorice: isolation and structure elucidation of a new benzofuran derivative by Demizu S, Kajiyama K, Takahashi K, Hiraga Y, Yamamoto S, Tamura Y, Okada K, Kinoshita T.(PubMed)
(532) Antimicrobial flavonoids from Glycyrrhiza glabra hairy root cultures by Li W, Asada Y, Yoshikawa T.(PubMed)
(533) 18β-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract by Kim J1, Joo I, Kim H, Han Y.(PubMed)
(534) Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans by Messier C1, Grenier D.(PubMed)
(535) Gan cao(Complementary and Alternative Healing University)
(536) Glabridin, An isoflavan from licorice root, down-regulates iNOS expression and activity under high glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(537) Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis by Chen P1, Zhou X2, Zhang L2, Shan M2, Bao B2, Cao Y2, Kang A2, Ding A2.(PubMed)
(538) Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses by  Dorhoi A1, Dobrean V, Zăhan M, Virag P.(PubMed)
(539) Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A by Chu X1, Jiang L, Wei M, Yang X, Guan M, Xie X, Wei J, Liu D, Wang D.(PubMed)
(540) Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice by Makino T1, Shiraki Y, Mizukami H.(PubMed)

If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth result in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

                                                           Treatment

                                                In Traditional Chinese Medicine 

In traditional Chinese medicine, candidiasis is defined as a malfunction of the Triple Burner-related condition due to spleen and stomach disorder(401), causing excess fluid or phlegm in our system(402), weakening immune system(403)(402), leading to damp heat accumulates in the Lower, Middle and Upper Burner causes of candidiasis(401).

                                                   Cleansing TCM Herbs

Overgrowth of candida in TCM is considered as the accumulation of waste, phlegm and damp heat, toxins due to inability of spleen and stomach in digesting foods properly(401).

      Chinese Herbs for Lower and Middle burner causes of Candida Albicans Overgrowth

1. Long Dan Cao (Gentianae Radix)
Long can cao is also known as Gentian is a genus of flowering plants (Gentiana L), belonging to the family Gentianaceae. The bitter, cold and non toxic herb has been used in TCM as analgesic(407) and to treat inflammation(404)(406), stimulate the digestive system(407)(408), in regulation of production of bile(409)(411), hydrochloride acid(411)(413) and other digestive enzymes secretion from panceas(414) by clearing liver and gallbladder damp heat(419) as it enhances the functions of liver, gallbladder and stomach channels(410)(412). According to study, the herb contains 5 active iridoids (loganic acid, 6′-O-beta-D-glucopyranosylgentiopicroside, swertiamarin, gentiopicroside, sweroside)(405), responsible for some of pharmaceutical activities, including cardiovascular, antihepatotoxic, choleretic, hypoglycemic, analgesic, anti-inflammatory,….. activities(406).
According to The University of Hong Kong, Long gan cao showed effectively in inhibition of Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas gingivalis, through its anti microbial activities(418)

2. Huang Qin (Skullcap)
Huang qin is also known as skullcap, a genus of Scutellaria, belonging to the family Lamiaceae. The bitter and cold herb has been used in TCM as antihistamine(415), anti edema(415) and anti-toxin(415) agents and to promote bowel movements(416), treat hepatitis B(417) by clearing heat(419), drying fire, draining dampness(419) as it promotes the functions of gallbladder, large intestine, lung, stomach channels. According to Integrating Complementary Medicine into Veterinary Practice By Paula Jo Broadfoot, Richard E. Palmquist, Karen Johnston, Jiu Jia Wen, Barbara Fougere, skullcap exhibited anti inflammatory, anti allergic, anti microorganisms effects(419), probably through its antioxidant and stimulating immune activities(420).

3. Zhi Zi (Gardenia)
Zhi zi is also known as gardenia fruit, a genus of Gardenia, belonging to the family Rubiaceae, native to the tropical and subtropical regions of Africa, southern Asia, Australasia and Oceania. The bitter, cold and toxic herb has been used in TCM as  anti toxic and antimalarial(421) antibiotic, antibacterial (424) antithrombotic(423), including resistant bacteria carrying blaNDM-1 and Candida albicans(426) and anti-inflammatory(421) effects and to treat digestive disorder(425) by dispersing fire, clearing heat, draining dampness, expelling toxins as it enhances the functions of heart, liver, lung, stomach, triple warmer channels.

4. Mu Tong (Akebia caulis)
Mu Tong is also known as Akebia caulis, a genus of akebia, belonging to the family Lardizabalaceae. The bitter and cool herb has been used in TCM as antibiotic, (Including inhibition of a variety of pathogenic fungi, including candida albicans(428)) anti-tumor, anti-inflammatory(429), a diuretic(430) and a pain reliever agent(427)(429) and to calm pain on urination(428)(429) and clearing heat as it promotes the functions of bladder, heart, small intestine channels(428).

5. Che Qian Cao (Plaintain)
Che qian cao is also known as Plaintain, the common name for herbaceous plants of the genus Musa, native to Southeast Asia and Oceania. The sweet and cold herb has been used in TCM as antimicrobials agent(431)(432)  and to promote intestinal health, by blocking adhesion of intestinal pathogens(433), probably through its antioxidant(436) and Immunomodulatory(437) effects, treat damp heat in the lower burner channel(439) due to infection(431)(434)and sexual dysfunction(435), stop diarrhea(438) by clearing the liver and lungs and transforming phlegm as it promotes the functions of bladder, kidney, liver, lung channels(439).

6. Ze Xie (Alismatis Rhizoma)
Ze xie is also known as Alisma, a genus of flowering plants in the family Alismataceae, found in a variety of still water habitats all over the world. The sweet and cold herb has been used in TCM as antioxidant(450) agent and to treat painful and difficult urination, edema, atopic dermatitis(445), nephropathy, hypoglycemica(446), diabetes(449), inflammation(441)(444), diarrhea(442), leukorrhagia(443), caused by damp heat in the lower burner(440), by eliminating water(441), clearing heat and damp heat as its enhances the functions of kidney and bladder channels(440).
According to Shanghai University of Traditional Chinese Medicine, herbal formula Jianpi Huoxue Decoction, containing ze xie, effectively improved  intestinal permeability by allowing nutrients to pass through the gut, while blocking potentially toxins from entering(448).

7. Chai Hu (Radix Bupleuri)
Chai hu is also known as Buplerum, a genus Buplerum of plants of the Apiaceae family. The bitter and cold herd has been used in TCM as anthelmintic(453)(456), anti proliferative(456), antimicrobial(459) and anti stress(455) agent and to treat fever, cold, hepatitis(451), diabetes(452), irregular menses(59), prolapse of uterus(459), and prolapse of rectum(459) by clearing heat and resolving depression(457) and liver stagnation(458) as it promotes the functions of the liver, gallbladder, pericardium, triple burner channels.
According to studies, the herb also process a very strong antioxidant contents through its total phenolic compounds including B. falcatum, B. falcatum ‘Mishima’ and B. latissimum, via radical scavenging activity(454).

8. Etc.

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+ References
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(451) Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways by Kim SO¹, Park JY¹, Jeon SY¹, Yang CH², Kim MR¹.(PubMed)
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(459) Chai Hu(Complementary and Alternative Healing University)