The Mystery of Lime-Green Lizard Blood May Lead to Malaria Cure
“In addition to having the highest concentration of biliverdin recorded for any animal, these lizards have somehow evolved a resistance to bile pigment toxicity. Understanding the underlying physiological changes that have allowed these lizards to remain jaundice-free may translate to non-traditional approaches to specific health problems,” said lead author Zachary Rodriguez, a doctoral candidate in LSU Department of Biological Sciences Professor Chris Austin’s lab.
Prasinohaema prehensicauda is a green-blooded lizard with high concentrations of biliverdin, or a toxic green bile pigment, found in New Guinea.
Photo Credit: Chris Austin, LSU.
Austin has spearheaded many expeditions to the megadiverse island of New Guinea to discover and document reptile and amphibian diversity. Rodriguez, Austin and colleagues investigated the evolutionary history of green blood, which evolved in several species of New Guinea lizards. They examined 51 species of skinks, which included six species with green blood, two of which are species new to science. They discovered that there are four separate lineages of green-blooded lizards, and each likely shared a red-blooded ancestor.
Credit: LSU
“We were excited by the complex history of these animals and surprised by the breadth of green-blooded lineages across lizards,” Rodriguez said. Their results will be published on May 16 in Science Advances.
Mountains of the Madang Province Highlands in New Guinea where two species of green-blooded lizards live.
Photo Credit: Chris Austin, LSU.
Green blood likely emerged independently in various lizards, which suggests that green blood may have an adaptive value. Slightly elevated levels of bile pigments in other animals, including insects, fish and frogs, have played potentially positive roles in these animals. Previous studies have shown that bile pigment can act as an antioxidant scavenging free radicals as well as preventing disease during in vitro fertilization. However, the function of green bile pigment in these lizards is still uncertain.
“The green-blooded skinks of New Guinea are fascinating to me as a parasitologist because a similar liver product, bilirubin, is known to be toxic to human malaria parasites. Ongoing work with the Austin lab examines the potential effect of the green blood pigment on malaria and other parasites that infect these lizards,” said co-author Susan Perkins, curator and professor at the Sackler Institute for Comparative Genomics and the Division of Invertebrate Zoology, American Museum of Natural History.
The scientists examined DNA samples from 27 green-blooded lizards and 92 closely related red-blooded lizards. They determined that red blood was the most likely ancestral state and that green
Contacts and sources:
Louisiana State University
Citation: Multiple origins of green blood in New Guinea lizards.
Zachary B. Rodriguez, Susan L. Perkins, Christopher C. Austin. Science Advances, 2018; 4 (5): eaao5017 DOI: 10.1126/sciadv.aao5017
Source:
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