How to Protect Yourself Against Liver Cancer Naturally, PubMed Model Studies Suggest

Kyle J. Norton

Green tea may have a potentially hepoprotective effect in inhibited onset and progression of liver cancer, some institutes suggested.

Liver disease is a reduced function of liver, as a result of damage or injure, causing by medication, viral infection,….

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced “yin excessive syndrome” or “yang vacuity syndrome” including weaken immunity and painful case of GERD,… according to traditional Chinese medicine’s Yin-Yang theory.

Adding to slice of ginger in your beverage will do the trick of getting rid of yin over expression, recommended for long term users.

According to the joint study lead by the Zhujiang Hospital of Southern Medical University Guangzhou, in the review of the data base of PubMed, CNKI, Wanfang and Weipu databases, regular green tea drinking was associated to a significant reduction of risk of liver disease(1), including hepatocellular carcinoma, liver steatosis, hepatitis, liver cirrhosis and chronic liver disease.

Green tea demonstrated a reduced risk of liver disease regardless of the race and geography(1) of the patients resided such as Asian, American and European subgroups.

Liver cancer is a medical condition caused by cell growth disorderly and uncontrollably in the liver tissue.

At the later stage, the cancerous cells may travel a distance away to infect other healthy organs and tissues.

Epidemiological studies suggested that green tea bioactive phytochemicals Epigallocatechin gallate (EGCG) and Theaflavin (TF) displays a strong inhibition of liver cancer through several mechanisms.

In liver cancer animal model induced by chronic exposure of N-nitrosodiethylamine (NDEA), a carcinogenic and mutagenic organic compound, application of green tea bioactive compounds Epigallocatechin gallate (EGCG) and Theaflavin (TF) demonstrated a strong effect in reduced initiation of cancer formation and potential chemopreventive effect in pre and post treatment of the injected animal(5).

N-Nitrosodiethylamine (NDEA) is an inducer of  hepatocarcinogenic dialkylnitrosoamine, presented in tobacco smoke,………

Further observation of EGCG/TF action in inhibited over expression of liver cancer, researchers found that the compounds also induce cancer cell death, similarly to those of CD44-specific cell membrane binding combined with near-infrared irradiation in induction of cellular apoptosis(5).

High CD44-positive expression is associated to acute cancer cells.

More over, the restriction processes of EGCG/TF in modification of the onset of liver cancer development, was found to regulate multiple biogenesis involved maintaining a relatively stable equilibrium in organs tissues, during the carcinogenesis processes., including
* The self-renewal Wnt/β-catenin and Hh/Gli1 pathways with implication of cell cycle progression, apoptosis and cellular transformation and cell differentiation and

* Cell proliferation involved Cyclin D1, a protein required for progression through the G1 phase of the cell cycle; cMyc found in increased expression of many genes that can induce formation of cancer; and EGFR with strong impact in triggering cancer cell growth and division (proliferation) and cell survival.

* Tumor suppressor (E-cadherin), a type of cell adhesion molecule, with function involved in cancer progression and metastasis.(5)

Interestingly, the therapeutic efficacy of tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) also regulated the proteins expression of cell differentiation, polarity and proliferation(the self-renewal Wnt and Hedgehog (Hh) pathways)(6).during CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.

Where hedgehog (Hh) pathways is important signaling cascades involved tumor growth and metastasis.
Application of green tea bioactive tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) induced chemo preventive potential in maintain cell integrity at the 30 weeks of CCl4/N-nitosodiethylamine application(6).

Continuous administration of EGCG/TF once gain exerted a strong impact in reduced proliferation and increased apoptosis, as well as decreased function of hepatic progenitor cells (HPCs) in participated restoration of the cancerous liver tissue and population with cancer stem cell-like characteristics in liver carcinoma(6) observed by AFP and CD44 expression.in CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.

Also, during the restriction processes of EGCG/TF, the bioactive compounds also modulated
* The expression of tumor progression to a more invasive phenotype(phospho-β-catenin-Y-654), through enhancing Wnt signalling;

*The proliferation, migration and invasion of liver cancer gene, secreted frizzled-related proteins (SFRPs) due to SFRP1 is lost in cancer cells and over expresion of SFRP2 and 4 derived from the tumor stromain in initiated tumor proliferation, migration and invasion.

* The gene in control tumor suppressor(β-catenin)(6). Mutation β-catenin is associated to various diseases, including cancers.

In short, green tea EGCG/TF inhibited the contaminated cells inflicted by injection of CCl4/N-nitosodiethylamine to prevent the initiation of liver cancer through modulation of certain gene expressions involved in liver cancer initiation and progression.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its potential in inhibited liver cancer possibilities.

Intake of supplementation should be taken with especial care in prevention of acute liver toxicity.

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Author biography: Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)
(2) Green tea extract: a potential cause of acute liver failure by Patel SS1, Beer S, Kearney DL, Phillips G, Carter BA.(PubMed)
(3) Green tea extract: a potential cause of acute liver failure by Patel SS1, Beer S, Kearney DL, Phillips G, Carter BA.(PubMed)
(4) Acute liver failure induced by green tea extracts: case report and review of the literature by Molinari M1, Watt KD, Kruszyna T, Nelson R, Walsh M, Huang WY, Nashan B, Peltekian K.(PubMed)
(5) Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice by Sur S1, Pal D2, Roy R2, Barua A2, Roy A3, Saha P2, Panda CK4.(PubMed)
(6) Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways by Sur S1, Pal D2, Mandal S3, Roy A4, Panda CK5.(PubMed)