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Psychedelic DMT Mimics Near-Death Experience In The Brain

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A powerful psychedelic compound found in ayahuasca can model near-death experiences in the brain, a study has found.

Near-death experiences, or NDEs, are significant psychological events that occur close to actual or perceived impending death. Commonly reported aspects of NDEs include out of body experiences, feelings of transitioning to another world and of inner peace, many of which are also reported by users taking DMT.

DMT is a potent psychedelic found in certain plants and animals, and is the major psychoactive compound in ayahuasca, the psychedelic brew prepared from vines and used in ceremonies in south and central America.

Credit: Wikimedia Commons / Hieronymus Bosch

Researchers from Imperial College London set out to look at the similarities between the DMT experience and reports of NDEs. Their findings, published today in the journal Frontiers in Psychology, reveal a large overlap between those who have had NDEs and healthy volunteers administered DMT.

As part of the trial, the team looked at 13 healthy volunteers over two sessions, who were given intravenous DMT and placebo, receiving one of four doses of the compound. The research was carried out at the NIHR Imperial Clinical Research Facility. All volunteers were screened and overseen by medical staff throughout.

Researchers compared the participants’ experiences against a sample of 67 people who had previously reported actual NDEs and who had completed a standardised questionnaire to try and quantify their experiences. The group were asked a total of 16 questions including ‘Did scenes from your past come back to you?’ and ‘Did you see, or feel surrounded by, a brilliant light?’.

Following each dosing session, the 13 healthy volunteers filled out exactly the same questionnaire to find out what sort of experiences they had whilst on DMT and how this compared to the NDE group.

The team found that all volunteers scored above a given threshold for determining an NDE, showing that DMT could indeed mimic actual near death experiences and to a comparable intensity as those who have actually had an NDE.

Dr Robin Carhart-Harris, who leads the Psychedelic Research Group at Imperial and supervised the study, said: “These findings are important as they remind us that NDE occur because of significant changes in the way the brain is working, not because of something beyond the brain. DMT is a remarkable tool that can enable us to study and thus better understand the psychology and biology of dying.”

Professor David Nutt, Edmond J Safra Chair in Neuropsychopharmacology at Imperial, said: “These data suggest that the well-recognised life-changing effects of both DMT and NDE might have the same neuroscientific basis.”

PhD candidate Chris Timmermann, a member of the Psychedelic Research Group at Imperial and first author of the study, said: “Our findings show a striking similarity between the types of experiences people are having when they take DMT and people who have reported a near-death experience.”

The researchers note some subtle, but important differences between DMT and NDE responses, however. DMT was more likely to be associated with feelings of ‘entering an unearthly realm’, whereas actual NDEs brought stronger feelings of ‘coming to a point of no return’. The team explain that this may be down to context, with volunteers being screened, undergoing psychological preparation beforehand and being monitored through in a ‘safe’ environment.

“Emotions and context are particularly important in near-death experiences and with psychedelic substances,” explains Timmermann. “While there may be some overlap between NDE and DMT-induced experiences, the contexts in which they occur are very different.”

“DMT is a potent psychedelic and it may be that it is able to alter brain activity in a similar fashion as when NDEs occur.

“We hope to conduct further studies to measure the changes in brain activity that occur when people have taken the compound. This, together with other work, will help us to explore not only the effects on the brain, but whether they might possibly be of medicinal benefit in future.”

The authors caution that while the initial findings are interesting, they advise against self-medication with ayahuasca.

Contacts and sources:
Imperial College London

Citation: “DMT models the near-death experience” by Christopher Timmermann et al. is published in the journal Frontiers in Psychology. DOI: 10.3389/fpsyg.2018.01424


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    Total 3 comments
    • Jobe Smith

      We secrete DMT from the pineal gland all the time when we got a astral projection incoscient or not and when we dies. Niice study to comprove that.

      • Anonymous

        WTF??? :smile:

    • Anonymous

      Novichok or Near Death Experience ???

      I think that this guy didn’t just find a bottle of what looked like perfume lying around ……I think he brought the drug from some dealer and he has brought it before…..as a substitute for heroin

      It is quite possible that an underground trend/phenomenon/practice/ has been taking place throughout the UK ….un-noticed by the general public and ignored (up-until-now) by the government and media……..It may be that “cottage” laboratories have/are being set up all over the country by “entreprenuer” amateur chemists in order to manufacture …distribute and sell designer fentanyl drugs (these fentanyl based drugs are quasi nerve-agents) …the ultimate high ….more powerful than heroin based opiates…..a “high” so intense you could call it a “near death experience”……..

      But why I hear you ask would someone want to have a near “death experience” in order to get high…???

      Well ….there is a sexual practice amongst some individuals where the experience is said to be almost
      “divine”……it’s called auto asphyxiation……couples during sex may take turns to deprive their partner of oxygen just before reaching orgasm by placing a plastic bag over the head and almost suffocatiing their sexual partner

      The entire “russia is attacking us with nerve agents” meme (narrative) may be a smoke screen to hide the fact that there might be a tsunami of “bio-hacking” cottage factories geared toward developing “ultimate” highs

      “Witnesses” said that Sergei was sitting on the bench waving his hands in the sky …looking like he was “tripping-out”……There’s a very good chance that he was poisoned by BZ or some other “new-guy” designer drug ….as well as the latest victims

      http://www.moonofalabama.org/2018/04/where-the-skripals-buzzed-novi-shocked-or-neither-may-has-some-splaining-to-do.html

      https://gab.ai/BlueSmokingHand/posts/23979145

      https://twitter.com/FluorescentGrey/status/985705472551305218

      https://www.rt.com/news/424149-skripal-poisoning-bz-lavrov/

      jacobs ladder _ https://www.youtube.com/watch?v=rJztRnDxdM8

      Fentanyl Poisoning ?

      http://www.investmentwatchblog.com/the-fentanyl-cover-up-in-the-skripal-poisoning-case/

      https://yournewswire.com/salisbury-sergei-skripal-poisoned-fentanyl/

      http://www.frombehindenemylines.org.uk/2018/03/novichok-or-fentanyl-no-proof-of-a-crime-points-to-skripal-poisoning-hoax/

      https://www.thedailybeast.com/sorry-i-developed-the-weapon-that-poisoned-a-russian-spy

      Rise in number of fentanyl deaths

      https://www.theguardian.com/society/2018/aug/06/fentanyl-drug-deaths-rise-nearly-third-england-wales

      Nebraska set to become first US state to use fentanyl in execution

      https://www.theguardian.com/world/2018/aug/13/nebraska-fentanyl-execution-first-state-us-carey-dean-moore-death-row

      Getting rid of the evidence ???

      https://www.express.co.uk/news/uk/1001990/Salisbury-explosion-Porton-Down-Wiltshire-Police-Netton-Chemring-Countermeasures

      The below is quoted from a book written about Russia during the transition years, 1990 – 1996 …..

      “Novichok” meaning “new guy”, or “newbie”, in geekspeak, any new product on any old scene can be designated a “novichok” there. I suspect that this is being done to designate fentanyl compounds “Russian developed novichok.” the stretch being done to put a tweak of “technical truth” in an otherwise credulity-challenged accusation.

      It would explain a “novichok” acting like a fentanyl, instead of a truly deadly agent…
      COMRADE CRIMINAL‭ ‬–‭ ‬Stephen Handelman
      Yale University Press‭ ‬1995

      [Page‭ ‬202‭]
      “In early‭ ‬1993,‭ ‬the rector of the Moscow Institute of Chemical Technology was handed a paper documenting the scientific work of four young prisoners.‭ ‬He was impressed.‭ “‬If you free them immediately,‭ “ ‬he joked to police,‭ “‬I’ll award them all doctorates of chemistry and put them to work in my institute.‭”
      “There was little chance of that happening.‭ ‬A year earlier,‭ ‬the four prisoners,‭ ‬all under thirty,‭ ‬had been chemistry students at the leading science college in Kazan,‭ ‬capitol of the Russian autonomous provinde of Tatarstan.‭ ‬They were regarded by their teachers and fellow students as the most brilliant in their class‭ ‬—‭ ‬so brilliant,‭ ‬in fact,‭ ‬that they soon grew bored with their formal studies.‭ ‬Working in the school laboratory aftefr hours,‭ ‬they produced an extraordinary drug.‭ ‬It was a dry white powder several times more potent than heroin and almost impossible to detect when mixed with water.‭ ‬The drug was trimethyl phentanyl,‭ ‬often called‭ “‬3MF‭” ‬by Russians.
      ‭ “‬What began as a student lark became a thriving criminal enterprise.‭ ‬Their work came to the attention of Moscow gangland figures,‭ ‬who offered them a contract for as much of the drug as they could produce.‭ ‬Soon the university laboratory became part of an intricate drug chain.‭ ‬The students,‭ ‬themselves,‭ ‬brought their worki to Moscow,‭ ‬whence the drug was trnsported to secret refining labs in Azerbaijan.‭ ‬There it was‭ “
      [Page‭ ‬203‭]
      “ mixed with distilled water and processed into five milliliter capsules.‭ ‬Thousands of the tiny capsules were soon making their way around Russia.‭ ‬Selling for five thousand rubles a capsule,‭ ‬3MF was the drug of choice for the elite by‭ ‬1992.‭ ‬It was eagerly consumed by the country’s new millionaires,‭ ‬athletes,‭ ‬rock musicians,‭ ‬politicians‭ ‬–‭ ‬and even discriminating gangsters.
      ‭ “‬In late‭ ‬1992‭ ‬several dozen mobsters gathered in a swank restaurant in Moscow‭ ‬…
      ‭ “ ” ‬Around this room we have gathered the very best people of our brotherhood,‭” ‬said one‭ ‬…‭ “‬But it is a great shame that the majority of us are seriously addicted.‭”
      “When he spoke the room was aleady half empty.‭ ‬Most of the parfty were in the toilets taking‭ ‬3MF.
      ‭ “‬…
      ‭ “‬When police followed the‭ ‬3MF trail back to the student chemists,‭ ‬they were stunned.‭ “‬These youngsters were real professionals,‭ ‬just like intelligence agents,‭” ‬said Col.‭ ‬Arkadi Kuznetsov,‭ ‬deputy head of the MVD’s drug control division,‭ “‬It took us a long time to get them,‭ ‬because they eluded our surveillance.‭ ‬Once they passed the powder to their business partners by throwing it through the closing door of a Moscow subway train to a contact waiting inside.‭” “
      …‭ ‬…‭ ‬…
      ‭[‬Page‭ ‬204‭]
      …‭ ‬…‭ ‬…
      ‭ “‬The breakup of the student drug ring came too late.‭ ‬Moscow was being flooded with thousands of‭ ‬3MF capsules a day,‭ ‬long after the young chemists went to prison.‭ ‬By then their secret formula was guiding the work‭ [‬of‭] ‬underground laboratories from Baku to Riga.‭ ‬The story of‭ ‬3MF proved that the credit for Russia’s drug boom belonged not just to domestic gangsters,‭ ‬bureaucrats,‭ ‬and scheming international drug lords.‭ ‬The children of the New Russia had earned a right to share in it.‭”

      I recommend the entire book. It is credible reporting, and covers aspects of the Russian transition that are particularly relevant in defining the milieu of the time Sergei Skripal came from, when he came, into British Service in 1995, when there was no Cold War and, theoretically, no longer animosity between Britain and Russia (which means Sergei could only work with MI6 then not be a double agent). I would suspect he got into trouble for becoming addicted to his MI6 paycheck (about 900 a month if he earned 100,000 in ten years from 1995 through 2004) and not quitting when relations with Britain soured when Putin took over from Yeltsin.

      http://www.theblogmire.com/debunking-the-first-piece-of-nonsense-in-skripal-2-0/#comment-5846

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