Read the Beforeitsnews.com story here. Advertise at Before It's News here.
Profile image
By Alton Parrish (Reporter)
Contributor profile | More stories
Story Views
Now:
Last hour:
Last 24 hours:
Total:

Tracking Our Cellular Lineage from One Cell at Conception to 37 Trillion Cells

% of readers think this story is Fact. Add your two cents.


One of great mysteries of human biology is how a single cell can give rise to the 37 trillion cells contained in the average body, each with its own specialized role. Researchers at Yale University and the Mayo Clinic have devised a way to recreate the earliest stages of cellular development that produces such an amazing diversity of cell types.

Using skin cells harvested from two living humans, researchers in the lab of Yale’s Flora Vaccarino were able to track their cellular lineage by identifying tiny variations or mutations contained within the genomes of those cells.

Credit: (© stock.adobe.com)

These “somatic” or non-inherited mutations are generated at each cell division during a human’s development. The percentage of cells bearing the traces of any given mutation decreases as these divisions continue, essentially leaving for scientists a trail to follow back to the earliest cells. If the fraction of cells with traces of a mutation is high, scientists know that the mutation was generated earlier in the cells’ lineage, closer to its one common ancestor during early embryonic development.

“It’s like Ancestry.com for our bodies,’’ said Vaccarino, the Harris Professor in the Yale Child Study Center, professor of neuroscience, and co-senior author of the research published March 18 in the journal Science.

Researchers knew some mutations within the skin cells were generated early in embryonic development because they could also be detected in adult samples of blood, saliva, and urine. In the human body, each of those specialized tissues arise from a different germ layer, or the first differentiated cell types in an embryo that give rise to nervous system, gut, blood, and connecting tissues.

The findings show that mutations generated in the embryo are inherited and retained by each daughter cell throughout the body’s development into adulthood, allowing researchers to reconstruct the early lineage trees for those individuals.

“Cellular history has consequences,” Vaccarino said.

The findings also may help scientists to trace developmental disorders back to their cellular beginnings. For instance, neuropsychiatric disorders such as schizophrenia and autism can arise from early cellular malfunctions that hijack early developmental regulators. This may alter the growth and expansion of certain cell lineages or when they separate to form new cell lines during development.

Intriguingly, the researchers also found that cell lineages that diverge at the first division tend to be asymmetrical. For instance, one of the first two daughter cells created in an embryo ends up accounting for as much as 90 percent of cell types in the adult body. The other daughter cell could be dedicated primarily to creating the placenta, which will nurture the growing embryo, the researchers say.

Vaccarino stressed that the technology to track individual differences in cellular ancestry during each step of cellular development is still limited.

But it is promising. “We have figured out a minimally invasive way to peer into a window of a person’s personal cellular history,” she said.

Alexej Abyzov of the Mayo Clinic is co-senior author of the paper. Co-first authors are Liana Fasching, a postdoctoral associate at the Yale School of Medicine, and Yeongjun Jang of the Mayo Clinic.

Contacts and sources:
Bill Hathaway
Yale University

 



Source:


Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Please Help Support BeforeitsNews by trying our Natural Health Products below!


Order by Phone at 888-809-8385 or online at https://mitocopper.com M - F 9am to 5pm EST


Order by Phone at 888-809-8385 or online at https://www.herbanomic.com M - F 9am to 5pm EST


Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!

HNEX HydroNano EXtracellular Water - Improve immune system health and reduce inflammation

Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.

MitoCopper - Bioavailable Copper destroys pathogens and gives you more energy. (See Blood Video)
Oxy Powder - Natural Colon Cleanser!  Cleans out toxic buildup with oxygen! 
Nascent Iodine - Promotes detoxification, mental focus and thyroid health.
Smart Meter Cover -  Reduces Smart Meter radiation by 96%!  (See Video)

Immusist Beverage Concentrate - Proprietary blend, formulated to reduce inflammation while hydrating and oxygenating the cells.

Report abuse
Loading...

Comments

Your Comments
Question   Razz  Sad   Evil  Exclaim  Smile  Redface  Biggrin  Surprised  Eek   Confused   Cool  LOL   Mad   Twisted  Rolleyes   Wink  Idea  Arrow  Neutral  Cry   Mr. Green

MOST RECENT
Load more ...

SignUp

Login

Newsletter

Email this story
Email this story

If you really want to ban this commenter, please write down the reason:

If you really want to disable all recommended stories, click on OK button. After that, you will be redirect to your options page.