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10 Reasons Why You Need to Eat Enough Zinc

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Zinc is an essential mineral for your health, so be sure you have enough zinc to keep you safe and enjoy a long life

Your body needs a variety of micronutrients and zinc is one of them. Zinc is anti-inflammatory, immunomodulatory, antioxidant, neuroprotective, cardio-protective and an infection fighter. Zinc deficiencies or lower levels of zinc in the body — caused by poor diet, oxidative stressors in the environment, the use of statin drugs and even natural aging — can lead to or increase your risk for a variety of health issues.

Optimal zinc levels may lower your risks for infections, cancers and heart diseases, increase your overall immunity and longevity, as well as help with inflammatory illnesses such as asthma, diabetes, neurological disorders and metabolic syndrome.

Eating your way to healthy zinc levels is easy — just follow the chart below for common zinc-rich foods. Daily zinc values recommended are 11 milligrams (mg) for men and 8 mg for women.


Oysters (3 oz, 38.3)

Beef (3 oz, 10.2)

Lamb (3 oz, 6.9)

Baked Beans with pork and tomato sauce (1/2 cup, 6.7)

Pork (3 oz, 5.7)

Sesame Seeds (1/2 cup, 5.1)

Cashews (1/2 cup, 3.8)

Pumpkin seeds (1/2 cup, 4.5)

Peanuts (1/2 cup, 3.2)

Crabs (3 oz, 3.2)

25% Fortified Cereals/Breads (1 serving, 2.8)

Turkey (3 oz, 2.8)

Chickpeas (1/2 cup raw, 2.8)

Cocoa (1/2 cup dry, 2.7)

Chicken (3 oz, 2.6)

Almonds (1/2 cup, 2.3)

Oatmeal (1 cup, 2.3)

Cheese (1/2 cup, 2.1)

Tofu (1/2 cup raw, 2.0)

Brown Rice (1/2 cup raw, 1.9)

Whole Wheat Pasta (1/2 cup dry, 1.4)

Lentils (1/2 cup, 1.3)

Greek Yogurt (6 oz, 1.0)

Dietary Supplements (5 mg to 40 mg)

Source: Office of Dietary Supplements. National Institutes of Health. Pubs. USDA National Nutrient Database for Standard Reference Release 28, Zinc Content.

1. Zinc Deficiency

A zinc deficiency impairs the immune system resulting in increased risk of infection. In a study of 32 children admitted to the hospital with dengue viral infections, 47% had a zinc deficiency. Fever duration and length of hospital stay were longer in zinc-deficient children compared to those who had normal levels.[i]

In a study of 1,253 patients diagnosed with coronary heart disease compared to a control group of 2,288 healthy patients, decreased zinc levels were found to be an independent risk factor for coronary heart disease.[ii]

In a study of pre-high blood pressure involving 142 apparently healthy subjects (90 women and 52 men ages 20 to 60 years) , scientists showed that a zinc deficiency was associated with pre-high blood pressure markers.[iii]

In a nutrition study of 182 infants and 207 preschoolers in rural Guatemala, anemia was found in 56% of the infants and 12% of preschoolers. The rates of iron and zinc deficiencies were 83%/75% and 63%/18% respectively for the two groups. Due to micronutrient deficiencies among these children, zinc and iron supplementation are beneficial to reduce anemia in rural areas.[iv]

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In a comprehensive research review, both in vitro and in vivo studies have shown an association between a zinc deficiency and increased risk of neurological disorders.[v]

In a seizure-induced rat model, a zinc-deficient diet for four weeks aggravated the long-term adverse effects of developmental seizures but a regimen of zinc supplementation for four weeks significantly improved damage-related changes to the neuronal membrane and cognition.[vi]

2. Oxidative Stress

Certain environmental issues — pollution, alcohol, tobacco smoke, heavy metals, transition metals, industrial solvents, pesticides, certain drugs like halothane, paracetamol and radiation — can induce imbalances in the body creating free radical-induced oxidative stress. Oxidative stress has been linked to Type 2 diabetes, neurodegenerative disorders, cardiovascular diseases, respiratory diseases, cataract development, rheumatoid arthritis and various cancers.[vii]

Adequate levels of zinc, since it is both an antioxidant and anti-inflammatory nutrient, are important to effectively reduce oxidative stress and inflammation, which, in turn, strengthens your immune system.[viii]

Excessive exposure to pesticides induces oxidative stress and has been linked to alterations in the lipid profile. In a study of 40 pesticide sprayers, supplementation with zinc significantly improved their oxidative stress markers and their lipid status.[ix]

In a clinical study of 105 diabetics, a supplement — 600 mg of α-lipoic acid, 165 mg of L-carnosin, 7.5 mg of zinc and B vitamins — was compared to a placebo. The food supplement with zinc improved glycemic control, lipid profile and antioxidative stress markers.[x]

Supplementation with zinc (30 mg), vitamin A (25,000 IU) and magnesium (250 mg) daily for 10 weeks in the treated group of 86 hypothyroid patients helped to improve thyroid function, oxidative stress and inflammatory markers.[xi]

3. Aging and Aging Skin

Aging is a natural occurrence over time with both biological and physical changes that can lead to disease, but enhancing nutrients such as zinc, selenium and niacin can help you age healthier and live longer.

Experiments performed “in vitro” on human cells and “in vivo” on zinc-deficient mice showed that zinc supplementation is important for immune efficiency, metabolic homeostasis and antioxidant activity. Niacin helped with DNA repair and maintaining genomic stability. Selenium provoked zinc release by metallothioneins.[xii]

Zinc supplementation improved the immune response in healthy elderly patients enrolled in a 48-day study by positively impacting the stress response during aging and acted as an antiaging mechanism in the immune system.[xiii]

In an aging mouse model, age-related zinc loss was found to contribute to T cell dysfunction and chronic inflammation. This immune dysfunction in the elderly is exacerbated by inadequate zinc dietary intake and improved with zinc supplementation.[xiv]

In a comprehensive review of research, supplementation with both selenium and zinc have antioxidant effects in the elderly by improving the decline of immune and cognitive functions and the pathogenesis of age-related disorders such as Type 2 diabetes.[xv]

A novel dietary supplement that included extracts from zinc, chamomile, grape seed, white tea, tomato and soy, fish protein polysaccharides, vitamins C and E provided improved condition, structure and firmness of aging skin in a six-month study of 80 post-menopausal women.[xvi]

4. Coronavirus Infection

In an observational study of 269 patients in a hospital intensive care unit (ICU), critically ill patients infected by coronavirus with severe acute respiratory distress syndrome were found to have a higher prevalence of low serum zinc levels.[xvii]

In a case versus control study with 30 controls and 90 cases of patients infected with coronavirus, the mean zinc level of cases was significantly lower than in controls. Among the patients, those with lower zinc levels had nearly double the risk of becoming hypoxic — oxygen deficient — and eventually needing oxygen support.[xviii]

5. Inflammation and Neuroinflammation

Foods and nutrients can be healing for your body. For example, vitamin D, vitamin E, zinc and probiotics have been shown to reduce infections while green tea, vitamin D and n-3 polyunsaturated fatty acids (PUFAs) help fight autoimmune and inflammatory disorders.[xix]

In a systematic review of the role of nutrition to counteract inflammatory and immune system responses in respiratory viruses such as rhinovirus, coronavirus, the flu and adenovirus, researchers recommended a predominantly anti-inflammatory diet that included turmeric, ginger, garlic, onions, saffron, vitamin C, vitamin D, zinc and omega-3 to reduce infection symptoms and duration.[xx]

In a study of 56 children with acute shinellosis — a severe bacterial infection associated with diarrhea and malnutrition, a 14-day course of 20 mg of zinc increased both inflammatory and immunity responses.[xxi]

Zinc homeostasis has been found to be crucial for your innate immune system, especially for maintaining the function of macrophages. Dysregulated zinc in macrophages causes impaired phagocytosis — your phagocyte cells can’t consume and destroy pathogens (like infections and bacteria) and infected cells — and an abnormal inflammatory response.[xxii]

In an in-vitro study of mice induced with neuroinflammation, zinc supplementation inhibited neural inflammatory responses mediated by microglia cells via upregulation of zinc-finger A20 and could be the underlying mechanism of the antidepressive effects of zinc found in previous studies.[xxiii]

6. Macular Degeneration

The eye has an unusually high concentration of zinc compared to other tissues. Review of research suggested that ocular zinc concentrations decrease with age, especially in the context of age-related diseases.[xxiv]

Some research has shown that 8 to 11 mg of zinc supplements can slow the progression of age-related macular degeneration (AMD) — an eye disease caused by aging.[xxv]

In a study of human donor eyes, reduced retinal pigment epithelium, choroid complex zinc and copper levels in AMD eyes were found. Zinc plus copper supplements reduced the risk of AMD progression and researchers concluded that metal homeostasis plays a role in AMD and retinal health.[xxvi]

Zinc monocysteine supplement of 25 mg twice daily was well tolerated and associated with improved macular function in comparison to a placebo in persons with dry AMD.[xxvii] Twenty-seven patients with nonadvanced AMD were divided into two age-similar groups: 15 patients had oral treatment of vitamin C (180 mg), vitamin E (30 mg), zinc (22.5 mg), copper (1 mg), lutein (10 mg), zeaxanthin (1 mg) and astaxanthin (4 mg) daily for 12 months and 12 patients had no dietary supplementation during the same period.

In nonadvanced AMD eyes, a selective dysfunction in the central retina (0 degrees to 5 degrees) can be improved with the carotenoids and antioxidant treatment but not in the more peripheral (5 to 20 degrees) retinal areas.[xxviii]

7. Low Testosterone

A deficiency in zinc has long been associated with testicular suppression, including suppression of testosterone levels.[xxix]

Dietary zinc intake was restricted — 2.7 to 5.0 mg daily — for 24 to 40 weeks in five male volunteers with a mean age of 57 years old. The baseline sperm concentration and total sperm count per ejaculate in all five subjects dropped significantly after zinc restriction and returned to normal six to 12 months after zinc supplementation, showing zinc’s effects on testicular function.[xxx]

Zinc supplementation of 40 marginally zinc-deficient normal elderly men for six months resulted in nearly doubling of testosterone.[xxxi] Zinc therapy also improved sexual competence of male rats in a dose-dependent manner over a period of two weeks.[xxxii]

8. Pneumonia

Your immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper and selenium, which play vital, often synergistic, roles at every stage of the immune response. Micronutrients with the strongest evidence for immune support include vitamins C and D and zinc, and additional supplementation is even more essential when the person is susceptible to stress, pollution or infections.[xxxiii]

In a study of 998 elderly from 33 nursing homes, subjects with normal final serum zinc concentrations after supplementation treatment had a lower incidence of pneumonia, almost 50% fewer new antibiotic prescriptions, a shorter duration of pneumonia, fewer days of antibiotic use and a reduction in all-cause mortality.[xxxiv]

In review of six randomized trials including 2,216 patients with severe pneumonia, giving zinc as an adjunct to the treatment of severe pneumonia was effective in reducing the mortality of the disease.[xxxv]

9. Cancers (All)

The anticancer effect of zinc is most often associated with its antioxidant properties, the influence of zinc on the immune system, transcription factors, cell differentiation and proliferation, DNA and RNA synthesis and repair, enzyme activation or inhibition, the regulation of cellular signaling and the stabilization of the cell structure and membranes.[xxxvi]

Higher levels of zinc decreased cancer risk in 12 types of cancers including bladder, breast, colon, esophageal, gastric, rectal, Hodgkin’s lymphoma, laryngeal, nasopharyngeal, oral, skin and vulva.[xxxvii]

In a review of 201 esophageal squamous cell carcinoma (ESCC) cases among 47,405 subjects enlisted in a nutritional study, higher intakes of calcium and zinc were associated with a lower risk of ESCC.[xxxviii]

In a zinc-deficient rat model, researchers found that zinc regulated an inflammatory pathway in esophageal cancer, which can be used as prevention and therapy for this type of cancer.[xxxix]

In a mammal study of macrophage cells, researchers discovered an immunostimulatory role for an iodine substituted zinc phtgalocyanine derivative, which produced significant changes in pro-inflammatory cytokine production levels[xl] and is proving effective for treating cervical,[xli] oral, head, neck and ocular cancers.[xlii]

10. Asthma

In a meta-analysis, lower circulating zinc and selenium levels were associated with an increased risk of asthma.[xliii]

In a study of 60 asthmatics and 30 apparently healthy volunteers, serum zinc levels were significantly lower in atopic asthmatics — their asthma is triggered by external allergens, such as dust, ozone, antibiotics, animals, pollen and food — than non-atopic asthmatics and healthy controls.[xliv]

In research of 76 asthmatic children, 72 participants had high oxidative stress, all participants had a zinc deficiency and nearly 40% of participants had a vitamin C deficiency. Vitamin C deficiency was associated with severe asthma and airway obstruction. Supplementation with vitamin C and zinc positively correlated with improved asthma relief and pulmonary functions, respectively.[xlv]

Powerful Reasons to Optimize Your Zinc Intake

With at least 10 compelling reasons, it makes sense to eat more zinc-rich foods such as oysters, crabs, meats, seeds, nuts, lentils/beans, oatmeal, cheese and yogurt. In addition to lowering your risk for serious diseases like cancers, heart attacks, asthma, brain disorders, diabetes, pneumonia and viral infections, zinc can also improve skin quality, testosterone, eye health and the ability to age better.

Zinc packs a punch by being an antioxidant, anti-inflammatory and immunity builder. To read more, please see’s research on zinc and zinc deficiency.


[i] Lakkana Rerksuppaphol, Sanguansak Rerksuppaphol. Zinc deficiency in children with Dengue viral infection. Pediatr Rep. 2019 Feb 26 ;11(1):7386. Epub 2019 Feb 26. PMID: 30838119

[ii] Heyu Meng, Yueying Wang, Fengfeng Zhou, Jianjun Ruan, Meiyu Duan, Xue Wang, Qiong Yu, Ping Yang, Weiwei Chen, Fanbo Meng. Reduced Serum Zinc Ion Concentration Is Associated with Coronary Heart Disease. Biol Trace Elem Res. 2021 Jan 2. Epub 2021 Jan 2. PMID: 33387273

[iii] Sara C Nevárez-López, Luis E Simental-Mendía, Fernando Guerrero-Romero, Jorge A Burciaga-Nava. Zinc deficiency is an independent risk factor for prehypertension in healthy subjects. Int J Vitam Nutr Res. 2019 Jul 1:1-6. Epub 2019 Jul 1. PMID: 31262235

[iv] Ana Palacios, Kristen Hurley, Silvia De Ponce, Victor Alfonso, Nicholas Tilton, Kaley Lambden, Gregory Reinhart, Jeanne Freeland-Graves, Lisa Villanueva, Maureen Black. Zinc Deficiency Is Associated with Anemia Among Children Under 24 Months-of-age in Rural Guatemala (P10-111-19). Curr Dev Nutr. 2019 Jun ;3(Suppl 1). Epub 2019 Jun 13. PMID: 31225086

[v] Vijay Kumar, Ashok Kumar, Kritanjali Singh, Kapil Avasthi, Jong-Joo Kim. Neurobiology of zinc and its role in neurogenesis. Eur J Nutr. 2021 Feb ;60(1):55-64. Epub 2021 Jan 5. PMID: 33399973

[vi] Ni-Na Chen, Dong-Jing Zhao, Yu-Xiao Sun, Dan-Dan Wang, Hong Ni. Long-Term Effects of Zinc Deficiency and Zinc Supplementation on Developmental Seizure-Induced Brain Damage and the Underlying GPR39/ZnT-3 and MBP Expression in the Hippocampus. Front Neurosci. 2019 ;13:920. Epub 2019 Sep 4. PMID: 31551684

[vii] Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015 Jan;30(1):11-26. doi: 10.1007/s12291-014-0446-0. Epub 2014 Jul 15. PMID: 25646037; PMCID: PMC4310837.

[viii] Mohammed Iddir, Alex Brito, Giulia Dingeo, Sofia Sosa Fernandez Del Campo, Hanen Samouda, Michael R La Frano, Torsten Bohn. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients. 2020 May 27 ;12(6). Epub 2020 May 27. PMID: 32471251

[ix] Amal Saad-Hussein, Khadiga S Ibrahim, Mohgah Sh Abdalla, Hatem A El-Mezayen, Nehal F A Osman. Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers. J Complement Integr Med. 2019 Aug 15. Epub 2019 Aug 15. PMID: 31421040

[x] Giuseppe Derosa, Angela D’Angelo, Davide Romano, Pamela Maffioli. A Clinical Trial about a Food Supplement Containingα-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients. Int J Mol Sci. 2016 Oct 28 ;17(11). Epub 2016 Oct 28. PMID: 27801825

[xi] Elaheh Rabbani, Fatemeh Golgiri, Leila Janani, Nariman Moradi, Soudabeh Fallah, Behnaz Abiri, Mohammadreza Vafa. Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021 Nov ;199(11):4074-4083. Epub 2021 Jan 7. PMID: 33409923

[xii] E Mocchegiani, M Malavolta, E Muti, L Costarelli, C Cipriano, F Piacenza, S Tesei, R Giacconi, F Lattanzio. Zinc, metallothioneins and longevity: interrelationships with niacin and selenium. Curr Pharm Des. 2008;14(26):2719-32. PMID: 18991691

[xiii] Akos Putics, Dalma Vödrös, Marco Malavolta, Eugenio Mocchegiani, Péter Csermely, Csaba Soti. Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes. Exp Gerontol. 2008 May;43(5):452-61. Epub 2008 Jan 15. PMID: 18304769

[xiv] Carmen P Wong, Kathy R Magnusson, Thomas J Sharpton, Emily Ho. Effects of zinc status on age-related T cell dysfunction and chronic inflammation. Biometals. 2021 Jan 3. Epub 2021 Jan 3. PMID: 33392795

[xv] Holger Steinbrenner, Lars-Oliver Klotz. Selenium and zinc:”antioxidants”for healthy aging? Z Gerontol Geriatr. 2020 May 28. Epub 2020 May 28. PMID: 32468295

[xvi] G R Lange Skovgaard, A S Jensen, M L Sigler. Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr. 2006 Oct;60(10):1201-6. Epub 2006 May 3. PMID: 16670692

[xvii] Thiago Jose Martins Gonçalves, Sandra Elisa Adami Batista Gonçalves, Andreia Guarnieri, Rodrigo Cristovão Risegato, Maysa Penteado Guimarães, Daniella Cabral de Freitas, Alvaro Razuk-Filho, Pedro Batista Benedito Junior, Eduardo Fagundes Parrillo. Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus (SARS-CoV-2). Nutr Clin Pract. 2020 Dec 23. Epub 2020 Dec 23. PMID: 33368619

[xviii] K A Talha, M I Patwary, Z N Alam, S M Ali, S Ahmed, A Nafee, F Selina, M H Khan, F R Shusmita, S G Avi, M N Rahman. Case-Control Study to Evaluate Zinc Deficiency as a Risk Factor for Oxygen Requirement in Patients with COVID-19. Mymensingh Med J. 2022 Jan ;31(1):216-222.

[xix] Dayong Wu, Erin D Lewis, Munyong Pae, Simin Nikbin Meydani. Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Front Immunol. 2018 ;9:3160. Epub 2019 Jan 15. PMID: 30697214

[xx] Farhad Vahid, Diana Rahmani. Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases? A systematic narrative review. Clin Nutr ESPEN. 2021 06 ;43:9-15. Epub 2021 Apr 24. PMID: 34024569

[xxi] Rubhana Raqib, Swapan Kumar Roy, Muhammad Jubayer Rahman, Tasnim Azim, Syeda Shegufta Ameer, Jobayer Chisti, Jan Andersson. Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr. 2004 Mar ;79(3):444-50. PMID: 14985220

[xxii] Hong Gao, Wei Dai, Lu Zhao, Junxia Min, Fudi Wang. The Role of Zinc and Zinc Homeostasis in Macrophage Function. J Immunol Res. 2018 ;2018:6872621. Epub 2018 Dec 6. PMID: 30622979

[xxiii] Li Hongxia, Tang Yuxiao, Shen Zhilei, Sun Yan, Qu Yicui, Shen Jiamin, Xu Xin, Yang Jianxin, Mo Fengfeng, Shen Hui. Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells. J Affect Disord. 2019 Apr 15 ;249:136-142. Epub 2019 Feb 12. PMID: 30772740

[xxiv] Rosie Gilbert, Tunde Peto, Imre Lengyel, Eszter Emri. Zinc Nutrition and Inflammation in the Aging Retina. Mol Nutr Food Res. 2019 08 ;63(15):e1801049. Epub 2019 Jun 27. PMID: 31148351

[xxv] Web MD. Eye Health. Zinc Vision.

[xxvi] Jay C Erie, Jonathan A Good, John A Butz, Jose S Pulido. Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration. Am J Ophthalmol. 2009 Feb;147(2):276-282.e1. Epub 2008 Oct 9. PMID: 18848316

[xxvii] David A Newsome. A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration. Curr Eye Res. 2008 Jul;33(7):591-8. PMID: 18600492

[xxviii] Vincenzo Parisi, Massimiliano Tedeschi, Geltrude Gallinaro, Monica Varano, Sandro Saviano, Stefano Piermarocchi,. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. Ophthalmology. 2008 Feb;115(2):324-333.e2. Epub 2007 Aug 22. PMID: 17716735

[xxix] Green Med Info. Blog. Five Evidence Based Ways to Boost Testosterone.

[xxx] A A Abbasi, A S Prasad, P Rabbani, E DuMouchelle. Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med. 1980 Sep ;96(3):544-50. PMID: 6772723

[xxxi] A S Prasad, C S Mantzoros, F W Beck, J W Hess, G J Brewer. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May;12(5):344-8. PMID: 8875519

[xxxii] Dmab Dissanayake, P S Wijesinghe, W D Ratnasooriya, S Wimalasena. Effects of zinc supplementation on sexual behavior of male rats. J Hum Reprod Sci. 2009 Jul;2(2):57-61. PMID: 19881149

[xxxiii] Adrian F Gombart, Adeline Pierre, Silvia Maggini. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020 Jan 16 ;12(1). Epub 2020 Jan 16. PMID: 31963293

[xxxiv] Simin N Meydani, Junaidah B Barnett, Gerard E Dallal, Basil C Fine, Paul F Jacques, Lynette S Leka, Davidson H Hamer. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr. 2007 Oct;86(4):1167-73. PMID: 17921398

[xxxv] Wang L, Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: A meta-analysis of randomized, double-blind and placebo-controlled trials. Clin Respir J. 2018 Mar;12(3):857-864. doi: 10.1111/crj.12646. Epub 2017 May 31. PMID: 28488366.

[xxxvi] Dorota Skrajnowska, Barbara Bobrowska-Korczak. Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms. Nutrients. 2019 Sep 22 ;11(10). Epub 2019 Sep 22. PMID: 31546724

[xxxvii] William B Grant. An ecological study of cancer mortality rates including indices for dietary iron and zinc. Anticancer Res. 2008 May-Jun;28(3B):1955-63. PMID: 18630488

[xxxviii] Maryam Hashemian, Hossein Poustchi, Christian C Abnet, Paolo Boffetta, Sanford M Dawsey, Paul J Brennan, Paul Pharoah, Arash Etemadi, Farin Kamangar, Maryam Sharafkhah, Azita Hekmatdoost, Reza Malekzadeh. Dietary intake of minerals and risk of esophageal squamous cell carcinoma: results from the Golestan Cohort Study. Am J Clin Nutr. 2015 May 27. Epub 2015 May 27. PMID: 26016858

[xxxix] Cristian Taccioli, Shao-Gui Wan, Chang-Gong Liu, Hansjuerg Alder, Stefano Volinia, John L Farber, Carlo M Croce, Louise Y Y Fong. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology. 2008 Nov 24. PMID: 19111725

[xl] Furkan Ayaz, Abdulcelil Yuzer, Mine Ince. Immunostimulatory effect of Zinc Phthalocyanine derivatives on macrophages based on the pro-inflammatory TNFα and IL1β cytokine production levels. Toxicol In Vitro. 2018 Dec ;53:172-177. Epub 2018 Aug 23. PMID: 30144574

[xli] Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R. Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs. 2021 Feb;39(1):89-97. doi: 10.1007/s10637-020-00990-7. Epub 2020 Aug 24. PMID: 32833137.

[xlii] Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Janani Panneerselvam, Akhil Srivastava, Rebaz Ahmed, Meghna Mehta, Anupama Munshi, Rajagopal Ramesh, Chapter Five – Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery, Editor(s): Kenneth D. Tew, Paul B. Fisher, Advances in Cancer Research, Academic Press, Volume 137, 2018, 115-170,

[xliii] Meng Chen, Yongye Sun, Yili Wu. Lower circulating zinc and selenium levels are associated with an increased risk of asthma: evidence from a meta-analysis. Public Health Nutr. 2019 Nov 5:1-8. Epub 2019 Nov 5. PMID: 31685060

[xliv] Nesrine A Mohamed, Marwa Rushdy, Asmaa S M Abdel-Rehim. The immunomodulatory role of zinc in asthmatic patients. Cytokine. 2018 Apr 18. Epub 2018 Apr 18. PMID: 29680371

[xlv] Siriporn Siripornpanich, Nalinee Chongviriyaphan, Wiparat Manuyakorn, Ponpan Matangkasombut. Zinc and vitamin C deficiencies associate with poor pulmonary function in children with persistent asthma. Asian Pac J Allergy Immunol. 2020 Dec 2. Epub 2020 Dec 2. PMID: 33274952

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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