Alzheimer's treatment with iron modifying drugs

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University of Warwick:

DIETARY IRON is an essential element in the brain. That’s why it is critical to understand how it affects Alzheimer’s. Researchers used advanced X-ray techniques to take a giant step forward in understanding iron chemistry in amyloid plaque, the main culprit behind Alzheimer’s. Learn more about their exciting new insights. 

Understanding the significance of these metals to the progression of Alzheimer’s could lead to more effective future therapies which combat the disease at its root. 

Dr Joanna Collingwood, Associate Professor at the University of Warwick’s School of Engineering and expert in trace metals analysis, high resolution imaging, and neurodegenerative disorders, commented:“Iron is an essential element in the brain, so it is critical to understand how its management is affected in Alzheimer’s disease. The advanced X-ray techniques that we used in this study have delivered a step-change in the level of information that we can obtain about iron chemistry in the amyloid plaques. We are excited to have these new insights into how amyloid plaque formation influences iron chemistry in the human brain, as our findings coincide with efforts by others to treat Alzheimer’s disease with iron-modifying drugs.” The team, led by an EPSRC-funded collaboration between University of Warwick and Keele University — and which includes researchers from University of Florida and The University of Texas at San Antonio — made their discovery by extracting amyloid plaque cores from two deceased patients who had a formal diagnosis of Alzheimer’s.
Scanning Alzheimer’s PlaqueThe researchers scanned the plaque cores using state-of-the-art X-ray microscopy at the Advanced Light Source in Berkeley, USA and at beamline I08 at the Diamond Light Source synchrotron in Oxfordshire, to determine the chemical properties of the minerals within them. 

They also analyzed the magnetic state of the iron species in the plaques to confirm the presence of various iron minerals including the magnetic iron oxide magnetite. 

The research team proposes that interactions between iron and amyloid that produce the chemically reduced iron species, including magnetite, may account for toxicity that contributes to the development and progression of Alzheimer’s. 

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