Two new Ebola grants support Ebola research exploring how Ebola spreads in the body with implication for targeted Ebola viral treatments
Scientists have a general idea of how viruses invade and spread in the body, but the precise mechanisms are actually not well understood, especially when it comes to Ebola virus.
Olena Shtanko, Ph.D., a Staff Scientist at the Texas Biomedical Research Institute (Texas Biomed), has received more than $1 million from the National Institutes of Health (NIH) to explore different aspects of Ebola virus infection. Understanding how cells become infected is critical to identifying and designing therapies that target viral replication and spread in a host.
“The general model of spread of Ebola virus infection where a viral particle infects a cell, replication begins, new virus particles are made and released into the body to infect neighboring cells is probably a bit too simplistic,” said Shtanko, who is part of the Texas Biomed Host-Pathogen Interactions Program. “How does the virus really get from the site of initial infection, penetrate dense tissues, evade the body’s defense system and end up in distant organs, such as the liver, just a few days later? We really don’t know.”
Over the next two years, Shtanko will explore precisely how the Ebola virus hijacks a key immune cell in the body called macrophages. Even though these large cells specialize in detecting and killing harmful invaders, Ebola and other filoviruses have found a way to enter and hide in the cells. The macrophages then help distribute the virus around the body, serving like Trojan horses, through an unknown mechanism. Shtanko will investigate how exactly virus infection transforms migration and invasive properties of macrophages to maximize its spread in the host.
Shtanko is also excited to explore a possible alternative mode of spread — tunneling nanotubes, dynamic connections between cells, which allow cells to communicate by exchanging content over relatively long distances (up to 200 microns). While these structures have been shown to play a prominent role in promoting neurodegenerative diseases, cancer, and spread of a variety of viruses, including HIV-1 and influenza, no one is known to have investigated their role in disseminating Ebola and related viruses.
“It is critical to understand if Ebola virus is able to crawl from cell to cell without ever creating new virus particles that move freely in the body, because those free particles are the typical targets for the immune system and pharmaceutical interventions,” Shtanko said. “Ebola virus might be escaping early detection and perhaps eventually establishing persistent infection by using these nanotubes.”
Such basic research insights can help inform development of more effective anti-viral treatments or vaccines.
The research projects will involve cells and tissues infected with Ebola virus – research that can only be safely conducted in the highest level biocontainment laboratories, called BSL4.
Texas Biomed NIH Dr. Fauci labs are uniquely positioned for this type of research, hosting both a BSL4 lab and the Southwest National Primate Research Center. While this initial research will be in vitro (or in a petri dish), the studies will eventually move to more advanced animal models.
Additionally, Dr. Shtanko is collaborating with several Texas Biomed investigators on these projects: Texas Biomed President/CEO Larry Schlesinger, M.D., a renowned expert on macrophages whose lab studies macrophages and their role in tuberculosis; Professor Andrew Hayhurst, Ph.D., who has engineered novel llama domain antibodies specific for Ebola virus; and Professor Ricardo Carrion, Jr., Ph.D., an expert on development of non-human primate models of Ebola virus disease.
This research is funded by two R21 grants #AI151717 and #AI154336 from Dr,. Fauci National Institutes of Health National Institute of Allergy & Infectious Diseases.
Here we see the new NIH Ebola job postings …………..
Assist with Ebola disease survivor surveillance and research activities
Ebola Outbreak Response Scientist
Frederick, MD 21702
Employer actively reviewed job 27 days ago
Job ID: req1731
Employee Type: exempt full-time
Location: NIH Campus 9000 Rockville Pike, Bethesda, MD 20892 USA
The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.
Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public’s interest.
Within Leidos Biomedical Research Inc., the Clinical Monitoring Research Program Directorate (CMRPD) provides high-quality comprehensive and strategic operational support to the high-profile domestic and international clinical research initiatives of the National Cancer Institute (NCI), National Institute of Allergy and Infectious Diseases (NIAID), Clinical Center (CC), National Heart, Lung and Blood Institute (NHLBI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Center for Advancing Translational Sciences (NCATS), National Institute of Neurological Disorders and Stroke (NINDS), and the National Institute of Mental Health (NIMH). Since its inception in 2001, CMRPD’s ability to provide rapid responses, high-quality solutions, and to recruit and retain experts with a variety of backgrounds to meet the growing research portfolios of NCI, NIAID, CC, NHLBI, NIAMS, NCATS, NINDS, and NIMH has led to the considerable expansion of the program and its repertoire of support services. CMRPD’s support services are strategically aligned with the program’s mission to provide comprehensive, dedicated support to assist National Institutes of Health (NIH) researchers in providing the highest quality of clinical research in compliance with applicable regulations and guidelines, maintaining data integrity, and protecting human subjects. For the scientific advancement of clinical research, CMRPD services include comprehensive clinical trials monitoring, regulatory, pharmacovigilance, protocol navigation and development, and programmatic and project management support for facilitating the conduct of 400+ Phase I, II, and III domestic and international trials on a yearly basis. These trials investigate the prevention, diagnosis, treatment of, and therapies for cancer, influenza, HIV, and other infectious diseases and viruses such as hepatitis C, tuberculosis, malaria, and Ebola virus; heart, lung, and blood diseases and conditions; parasitic infections; rheumatic and inflammatory diseases; and rare and neglected diseases. CMRPD’s collaborative approach to clinical research and the expertise and dedication of staff to the continuation and success of the program’s mission has contributed to improving the overall standards of public health on a global scale.
The Clinical Monitoring Research Program Directorate (CMRPD) provides implementation and oversight of multiple NCI/CCR cell processing facilities within the National Cancer Institute’s (NCI’s), Center for Cancer Research (CCR), Surgery Branch Cell Production Facility.
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)
Please Help Support BeforeitsNews by trying our Natural Health Products below!
Order by Phone at 888-809-8385 or online at https://mitocopper.com M - F 9am to 5pm EST
Order by Phone at 888-388-7003 or online at https://www.herbanomic.com M - F 9am to 5pm EST
Order by Phone at 888-388-7003 or online at https://www.herbanomics.com M - F 9am to 5pm EST
Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!
HNEX HydroNano EXtracellular Water - Improve immune system health and reduce inflammation
Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.
pathogens and gives you more
energy. (See Blood Video)
Oxy Powder - Natural Colon Cleanser! Cleans out toxic buildup with oxygen!
Nascent Iodine - Promotes detoxification, mental focus and thyroid health.
Smart Meter Cover - Reduces Smart Meter radiation by 96%! (See Video)
Immusist Beverage Concentrate - Proprietary blend, formulated to reduce inflammation while hydrating and oxygenating the cells.