Your Dog May Be Hiding its True Colors
Credit: Purdue University
If you have a purebred dog, it’s likely that he or she looks fairly similar to other dogs of the same breed, especially when it comes to the color of their coats.
But what happens if a purebred puppy doesn’t look exactly like its siblings when it’s born? Chances are, it might not be a flaw – but rather a hidden gene variant that decided to show itself.
New research from Purdue University’s College of Veterinary Medicine shows that some breeds of dogs have hidden coat colors – and in some cases, other traits – that have been lurking all along.
Led by Kari Ekenstedt, DVM, Ph.D., assistant professor of anatomy and genetics, and Dayna Dreger, Ph.D., the lead scientist in Ekenstedt’s canine genetics research laboratory, the team looked at a dozen different genes in 212 dog breeds. Purdue researchers, together with industry partners at Wisdom Health, analyzed data that had been initially collected by WISDOM PANEL™ for the development of canine DNA tests. The work was published Oct. 28 in PLOS ONE.
“These are purebred dogs with traits that their breed clubs say they’re not supposed to have,” said Ekenstedt, whose research program focuses on canine genetics. “The message of this paper is, ‘Hey, these gene variants exist in your breed, and if a few dogs are born with these traits, it’s not caused by accidental breeding and it’s not a mutt; it’s a purebred showing this known genetic potential.’”
Along with analyzing the data, researchers used standard breed descriptions from major American and international dog breed registries to determine coat colors and tail lengths that were accepted within each breed.
“There was a lot of information we didn’t expect,” Dreger said. “When it comes to different dog breeds, their standards are mostly based on preference and aesthetics. We make assumptions for certain breeds based on what we expect their coat colors to be.”
Ekenstedt says coat color genes have a significant amount of epistasis between them, meaning that what happens at one gene can mask what’s happening at another gene. Because of epistasis, it’s rare to see those masked genes actually expressed in a dog’s coat color.
One example of a “fault” allele – a gene variant that would cause a trait that is not allowed in a breed standard – is an allele that causes the brown color, which affects both hair pigment and skin pigment. The color is allowed in breeds like the Labrador Retriever where it causes the chocolate color. However, researchers observed that in breeds where brown is not allowed, such as the Rottweiler and the German Shepherd Dog, brown alleles exist at low frequencies.
Another example of a fault allele is in the Weimaraner, which exists in both longhaired and shorthaired varieties. At least one dog breed organization does not allow longhaired Weimaraners while several others do allow them. Of the Weimaraners sampled in this data, the longhaired allele is present at a 4% frequency.
The same goes for other traits, too, Dreger said. For example, there are around 18 recognized breeds of dogs that have the genetic potential to be born without a tail – such as the popular Australian Shepherd. But the data shows that up to 48 of the breeds analyzed possess the tailless gene variant, usually at a very low frequency; one of those breeds is the Dachshund.
“A breeder would certainly be surprised to see a Dachshund born without a tail,” Dreger said. “The chances are low, but our research shows that the potential is there.”
Both Dreger and Ekenstedt hope the research prompts some discussions within the dog community.
“I want this to start science-based conversations,” Dreger said. “We’re not here to make decisions on what a breed should or shouldn’t look like or what a breed club should do. We’re here to say these are the facts, and these are the gene variants that naturally exist in these breeds.”
They also hope it changes some perspectives when it comes to what is to be expected with certain breeds of dogs.
“There’s an assumption that the standards for these different breeds of dogs are set in stone,” Dreger said. “People will often make assumptions that if it doesn’t match this, it’s not purebred. This data shows that there is a lot of variation in some of these breeds, and the standards are not as concrete as we expect them to be.”
Wisdom Health funded a Veterinary Summer Scholar position to Blair Hooser, a student at the Purdue College of Veterinary Medicine and coauthor on the paper, for this work. Partial support for Dr. Ekenstedt was provided by the National Institutes of Health.
Contacts and sources:
Abbey Nickel, Kari Ekenstedt
Citation: True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential. Dayna L. Dreger, Blair N. Hooser, Angela M. Hughes, Balasubramanian Ganesan, Jonas Donner, Heidi Anderson, Lauren Holtvoigt, Kari J. Ekenstedt. PLOS ONE, 2019; 14 (10): e0223995 DOI: 10.1371/journal.pone.0223995
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