Ageing as approach of magnetic body and biological body to thermal equilibrium

There was an interesting a HREF=”https://scitechdaily.com/researchers-solve-anti-aging-mystery-identify-gene-responsible-for-cellular-aging”>article in Scitechdaily about ageing. The claim of the title of the article was that the gene responsible for ageing has been found.

The title of the article is somewhat misleading. David Sinclair emphasizes in this book Life Span that there is no gene for ageing. Rather, ageing can be understood as an outcome of the second law leading to molecular chaos at the level of DNA related molecules. He also emphasizes that epigenesis correspond to informtion processing in continuous degrees of freedom related to DNA geometry. In TGD these degrees of freedom would be associated with the magnetic body (MB) carrying dark matter as h_eff=nh₀ phases of ordinary matter and responsible for control and induction of the coherence of the ordinary biomatter from its own long scale quantum coherence.

The gene expression changes since the epigenetic control mechanisms involving for instance methylation and acetylation cease to function properly. The number of non-expressed genes increases. A chaotic behavior in the conformational degrees of freedom of DNA paired with dark DNA at its MB.

One can of course argue that there could exist an ageing gene. If cells would not age it would not take a long time for metabolic resources to deplete. However, the second law can generously take care of ageing.

Living systems are however able to fight against ageing. This is a mystery from the point of view of standard physics. One could argue that metabolic energy feed is enough but living systems are also critical and even quantum critical systems able to remain so: this is like a ball getting again and again at the top of the needle. How is this possible?

Here the zero energy ontology, which is behind TGD based quantum theory comes at rescue: “big” (ordinary) state function (BSFR) for subsystems changes the arrow of time and dissipation looks like self-organization and self-organized quantum criticality becomes possible. Generalized thermodynamics also allows metabolism as an extraction of even thermal energy from surroundings. Stress proteins could do this and be near physiological temperature and also act as heaters of DNA and proteins in cold shock and as heat engines driving molecular motors. Time reversal would happen also in the de-differentiation to stem cells.

Ageing would be basically heat death in this framework. The MBs of information molecules like DNA controlling them must be at much lower temperature than the physiological temperature otherwise they would not be information molecules. Physiological temperature would be near the maximal temperature – Hagedorn temperature of the string-like flux tubes of MB. The MBs however approach thermal equilibrium with the environment. Eventually heat death results and leads to BSFR (death followed life in reversed time direction) at the level of the entire organism.

For background see the article The based view about dark matter at the level of molecular biology written together with Reza Rastmanesh.

For a summary of earlier postings see Latest progress in TGD.

Articles and other material related to TGD.