Largest Brain Study of 62,454 Scans Identifies Drivers of Brain Aging
In the largest known brain imaging study, scientists from Amen Clinics (Costa Mesa, CA), Google, John’s Hopkins University, University of California, Los Angeles and the University of California, San Francisco evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging. SPECT evaluates regional cerebral blood flow in the brain that is reduced in various disorders.
Drivers of Brain Aging
Credit: Daniel G. Amen
The current study, which will appear in a forthcoming issue of the Journal of Alzheimer’s Disease, used brain SPECT imaging to determine aging trajectories in the brain and which common brain disorders predict abnormally accelerated aging. It examined these functional neuroimaging scans from a large multi-site psychiatric clinic from patients who had many different psychiatric disorders, including bipolar disorder, schizophrenia and attention deficit hyperactivity disorder (ADHD).
Commenting on the study, George Perry, PhD, Chief Scientist at the Brain Health Consortium from the University of Texas at San Antonio, said, “This is one of the first population-based imaging studies, and these large studies are essential to answer how to maintain brain structure and function during aging. The effect of modifiable and non-modifiable factors of brain aging will further guide advice to maintain cognitive function.”
Co-investigator Sachit Egan, Google Inc. (Mountain View, CA), said, “This paper represents an important step forward in our understanding of how the brain operates throughout the lifespan. The results indicate that we can predict an individual’s age based on patterns of cerebral blood flow. Additionally, groundwork has been laid to further explore how common psychiatric disorders can influence healthy patterns of cerebral blood flow.”
Contacts and sources:
Diana MurrayIOP Presss
Citation: “Patterns of Regional Cerebral Blood Flow as a Function of Age Throughout the Lifespan,” by Daniel G. Amen, Sachit Egan, Somayeh Meysami, Cyrus A. Raji and Noble George (DOI 10.3233/JAD-180598). This research is scheduled to be published in a forthcoming issue of the Journal of Alzheimer’s Disease published by IOS Press.
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