New Anticancer Agents May Better Control Tumor Growth in Nearly Every Cancer Type
A gene called MYC has become one of the hottest targets for cancer researchers around the world. MYC is known to drive tumor growth in nearly all cancer types – but successfully targeting the gene has proven to be a challenge. One that has been baffling researchers for more than three decades.
Now, researchers at Purdue University have discovered a novel set of MYC promoter G-quadruplex stabilizers that have demonstrated anticancer activity in human cancer cell cultures. The discovery is published in the July 8 edition of the Journal of the American Chemical Society.Purdue University researchers have discovered potential anticancer agents that stabilize the MYC promoter G-quadruplex and downregulate the expression of the MYC oncogene.
Credit: Purdue University/Danzhou Yang
The Purdue team discovered potential anticancer agents that target the MYC promoter G-quadruplex and downregulate the expression of the MYC oncogene, which is overexpressed in cancer and is associated with almost all aspects of cancer development. The work has been supported by the National Cancer Institute and the National Institutes of Health.
Cushman, whose cancer research work contributed to his election as a fellow of the National Academy of Inventors, said they discovered a novel class of indenoisoquinoline MYC promoter G-quadruplex stabilizers in collaboration with Danzhou Yang. Some of them also inhibit topoisomerase I, an enzyme that facilitates DNA replication and is produced in greater amounts in cancer cells.
Purdue University cancer and pharmacy researchers have discovered a novel set of MYC stabilizers that have demonstrated anticancer activity in human cancer cell cultures. Pictured are Guanhui Wu, a doctoral student, Mark Cushman, Danzhou Yang and Kaibo Wang, a postdoctoral research associate.
Credit: Purdue Research Foundation/Hope Sale
Yang and Cushman, both members of the Purdue University Center for Cancer Research, said the agents they discovered could be used in helping to treat nearly every type of cancer. Some of the technology from their work has been licensed to Gibson Oncology LLC through the Purdue Research Foundation Office of Technology Commercialization.
Some of the work Cushman and his team previously developed led to three anticancer agents that are in clinical trials. The MYC innovation will greatly enhance interest in these anticancer agents within the scientific community and will also contribute to the understanding of how they work.
Contacts and sources:
Order by Phone at 888-809-8385 or online at www.mitocopper.com
Get our Free Ebook, "Suppressed Health Secrets" THEY don't want you to know!
APeX - Far superior to colloidal silver! Desroys Viruses, Bacteria, Pathogens!
Ultimate Curcumin - Natural pain relief, reduce inflammation and so much more.
Supreme Fulvic - Nature's most important supplement! Vivid Dreams again!
MitoCopper - Bioavailable Copper destroys pathogens and gives you more energy.
Oxy Powder - Natural Colon Cleanser! Cleans out toxic buildup!
B-12 - Supports healthy metabolism, brain function, hormone balance!
Nascent Iodine - Promotes detoxification, mental focus and thyroid health.
Never Wax Your Car Again - Protects vehicles for years with dazzling shine!
Smart Meter Cover - Reduces Smart Meter radiation! See Video!
Prodovite - The Secret To Healing is in the Blood!
|New Laser Blinds Attackers Instantly!||Bring
|NASA - US Faces 100 Year Drought!||Discovery
Bills by 65%