NASA finds that Earth's fourth-largest lake is almost completely dry
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The Aral last dried up in the Middle ages, the area has had an unusually dry period combined with a Soviet era irrigation scheme for cotton plantations responsible for the pesticide residue. The Sea will not completely dissapear due to a dam being created to preserve the northern portion while measures are introduced to restore its volume.
Both events were partly due to irrigation, but mostly long term variability. Last Drying periods in the 7th C and around 13 th C when the Amu Darya river shifted its flows between the Uzboy and the Aral sea after the dam diverting the entire flow to the Aral was destroyed by Gengis Khan in 1221.
In fact the existence of the Aral sea in the form known was entirely due to the damming of the Amu Darya to re-create the sea after the 7th C, it is therefore man made.