Inability to metabolize Excipients in Vaccines & Cytochrome P450

Armed with Knowledge

VACCINE Excipients and Cyp P450:   Common excipients in Vaccines inhibit Cytochrome P450,the major detox mechanism in humans, plants and animals.   Considering Cyp 450 is immature in the infant and child,  the following excipients can’t be dealt with, released or detoxified in the infant and growing child.  It is to be noted that the inhibition of Cytochrome P450 and the inability to release the toxins from the body in cases of Adults cause serious psychotic events including suicide and “heinous” homicides.  Could these vaccine ingredients that are not metabolized by infants and children in various degrees appear like “mental illness”, hence the DSM misdiagnosis criteria?

The sample list of excipients below commonly injected MANY times into infants in many overlapping vaccines need Cyp 450 to metabolize yet some children, due to genetic variation,  are totally missing the activity of Cyp 450 and, in any case all children have immature Cyp 450 activity. This may give us one of the answers to the apparent range of vaccine injury in the general population.

Re: Polysorbate 80, a common vaccine excipient:

The results indicate that these non-ionic surfactants are in vitro inhibitors of CYP-mediated metabolism
Study…
http://www.ncbi.nlm.nih.gov/pubmed/21220010

RE:  Ethanol and Formaldehyde, vaccine excipients: 
Study…
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.320.1093&rep=r…

Re:  Alcohol, a vaccine excipient

RE: Benzethonium Chloride, a vaccine excipient
Notice that in the latest drug commercials they advertiser warns against Grapefruit seed extract.  This is because GSE inhibits Cytochrome P450 and therefore inhibits detoxifcation of toxic elements
Study….
http://www.ncbi.nlm.nih.gov/pubmed/17468864
Some manufacturers of GSE have stated that their extract has compounds nearly identical to benzethonium chloride

Phenol, a benzene metabolite, a vaccine excipient
Study…
http://www.ncbi.nlm.nih.gov/pubmed/11701230

Asthma, Allergies, Inflammation & the role of Cyp 450
Study…
http://www.sciencedirect.com/science/article/pii/S0003986106003791

Re: Aluminum Hydroxide adjuvant
Is Aluminum Hydroxide inhibiting the already immature activity of Cyp 450 that apparently is important in  reducing inflammation?
Study…
http://www.sciencedirect.com/science/article/pii/S0003986106003791
Cyp 450 and lungs

Aluminum Phosphate, a vaccine excipient and SHAKING BABY SYNDROME

Shaking Baby Syndrome & bone breaking symptoms:

Aluminum accumulation in bone has become much less frequent with cessation of use of aluminum-containing phosphate binders. Unfortunately, the binders which have largely replaced aluminum have not proven completely satisfactory

Study…

http://www2.kidney.org/professionals/KDOQI/guidelines_bone/Guide13B.htm

Osteomalacia – Mayo Clinic http://www.mayoclinic.org/diseases-conditions/osteomalacia/basics/definitio…
Osteomalacia refers to a softening of your bones, often caused by a vitamin D deficiency. Soft bones are more likely to bow and fracture than are harder, healthy bones.  Note:  As per the SBS & bone breaking symptom in the above link Aluminum – containing phosphae binders cause Osteomalacia as well.

Immaturity of Cyp 450 in infants (So why are we giving Hep B with
at one hour old?) Attached

Comment Hep B contains many of these excipient ingredients which an infant is unable to metabolize.  This is a point that can be made when writing a model Hep B bill.

SUPER CYP 450 DATA BANK:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808967/
SuperCYP (http://bioinformatics.charite.de/supercyp) is a comprehensive resource focused on CYPs and drug metabolism.

Layman’s talk on Cyp 450

Finally, it must be noted that non metabolism (polymorphism of cyp 450 aka lack of activity) runs in the family.
Parents and siblings will all be found to have the same polymorphism.

In addition to the MTHFR gene, there is a gene called the CYP450 pathway which is critical for effective detoxification. It is suppressed genetically in 43% of Africans. Unfortunately, CYP450 pathway affects the safety and efficacy of 90% of therapeutic drugs and other environmental chemicals.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868406/ http://www.ncbi.nlm.nih.gov/pubmed/23641907 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390790/ http://www.biomedcentral.com/1471-2156/14/34
http://www.nature.com/tpj/journal/v13/n1/full/tpj201245a.html

Furthermore, Latinos have a suppressed CYP3A4*10 enzyme and CYP3A4*16A enzyme.

http://www.pharmacologyweekly.com/articles/genetic-polymorphisms-cytochrome-P450-CYP3A4-enzyme
http://www.sciencedirect.com/science/article/pii/S0163725813000065 http://www.aafp.org/afp/2007/0801/p391.html
http://www.ncbi.nlm.nih.gov/pubmed/15364537
http://www.medscape.com/viewarticle/744945_3 http://www.hoajonline.com/jdrcm/2050-0866/1/22

https://books.google.com/books?id=XAfUAgAAQBAJ&pg=PA335&lpg=PA335&dq=hispanic+cyp450+enzyme&source=bl&ots=Eyzy37i1gr&sig=W8VMcXeAucdMmbGRgKlV2uThWAs&hl=en&sa=X&ei=mdEmVePCOsuWsAXJqIHgBw&ved=0CF0Q6AEwCA#v=onepage&q=hispanic%20cyp450%20enzyme&f=false http://www.fda.gov/downloads/Drugs/ScienceResearch/…/UCM085502.pdf?hc_location=ufi

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