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Two-step enhanced cancer therapy with genetically engineered Salmonella bacteria

Sunday, February 12, 2017 16:44
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Two bacteria can be better than one

In some cases, injecting tumors with specific bacteria can help eradicate the tumors by stimulating inflammation and triggering an antitumor immune response. A classic example of this is injection of bladder cancer with bacillus Calmette-Guérin, but more recent approaches have used bacteria such as Clostridium and Salmonella species. Building on the idea of antitumor bacterial therapy, Zheng et al. engineered a weakened strain of Salmonella typhimurium to produce the flagellin B protein from another bacterium, Vibrio vulnificus. The engineered bacteria induced an effective antitumor immune response, successfully treating tumors in several different mouse models with no evidence of toxicity.

Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin | Science Translational Medicine:



Source: http://gmopundit.blogspot.com/2017/02/two-step-enhanced-cancer-therapy-with.html

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