The Bio-Inkjet Printer For New Body Parts
By extending his pioneering acoustical work that applied sound waves to generate droplets from fluids, Dr. Utkan Demirci and his team at Harvard Medical School’s (Brigham and Women’s Hospital) Bio-Acoustic Mems in Medicine Laboratory report encouraging preliminary results at an early and crucial point in a stem cell’s career known as embroid body formation. Their research results appear in the journal Biomicrofluids, published by the American Institute of Physics.
Getting the embroid body formed correctly and without mechanical trauma is key to preserving the stem cells’ astounding ability to develop into any desired tissue. Their new automated bioprinting approach appears to do this better than manual pipetting in the “hang-drop” method traditionally used.
Notes Dr. Demirci: “To have the capability to manipulate cells in a high-throughput environment reliably and repeatedly, whether it is a single cell or tens of thousands of cells in a single droplet, has the potential to enable potential solutions to many problems in medicine and engineering.”
Three research results stand out:
- Enhanced uniformity of size and ability to control droplet size. These are key variables because they determine how the embroid bodies will grow.
- Achieving a scalable system that can print one cell or tens of thousands per droplet—a level of precise manipulation not previously available.
- Faster droplet formation. The new system delivers 160 droplets/seconds, versus 10 minutes for the hang-drop method.
The next step involves assessing the two methods to compare their effects on cell function. Says Dr. Demirci: “We are eager to take it to the next level.”
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