Curcumin: Spice Ingredient In Curry Emerges As Promising Basis For An Alzheimers Disease Medicine

The spice compound that gives curry dishes their yellow color and pungent flavor is emerging as a prime candidate for a less expensive treatment for Alzheimer’s disease (AD), according to an article in the current edition ofChemical & Engineering News. C&EN is the weekly newsmagazine of the American Chemical Society, the world’s largest scientific society.
Lauren K. Wolf, C&EN associate editor, explains that pharmaceutical companies have invested heavily in developing new drugs for AD. More than 5 million people in the U.S. alone already have that memory-robbing disease. Projections suggest that the number will rise to 16 million by 2050. New medications are in the pipeline, but the most advanced candidates, made of monoclonal antibodies, are expensive to produce and may cost tens of thousands of dollars annually to treat each patient.
As a result, scientists are seeking less-pricey alternatives, such as substances that can be extracted in abundant amounts from plant compounds. One of the most promising is curcumin, a spice compound extracted from the rootstalks of the turmeric plant. The article details scientific evidence about curcumin’s potential and the hurdles that chemists must overcome to craft it into a drug. For instance, only tiny amounts of powdered curcumin taken by mouth get into the blood, let alone the brain.
Turmeric has been used in India for over 2500 years and is a major part of the Ayurvedic system of medicine. It was first used as a dye and then later for its medicinal properties. The etymology of the word “turmeric” probably comes from the early French “terre merite” via the Latin “terra merita”, literally “deserving earth”
Turmeric paste is traditionally used by Indian women to keep them free of superfluous hair and as an antimicrobial. Turmeric paste, as part of both home remedies and Ayurveda, is also said to improve the skin and is touted as an anti-aging agent. Turmeric figures prominently in the bridal beautification ceremonies of India, Nepal, Bangladesh, and Pakistan. Staining oneself with turmeric is believed to improve the skin tone and tan. Turmeric is currently used in the formulation of some sunscreens.
Credit: Wikipedia
The government of Thailand is funding a project to extract and isolate tetrahydrocurcuminoids (THC) from turmeric. THCs are colorless compounds that might have antioxidant and skin-lightening properties, and might be used to treat skin inflammations, making these compounds useful in cosmetics formulations.
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