Severe lactic acidosis and Vitamin B1 deficiency
Home of Kyle J. Norton for The Better of Living & Living Health The vitamin B-complex are essential water-soluble vitamins, including vitamin B1(thiamine), vitamin B2 (riboflavin ), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), biotin, folic acid and vitamin B12 (cobalamins).
A. Vitamin B1 (Thiamine)
Severe lactic acidosis and Vitamin B1 deficiency
There was a report of a leukemic child treated with chemotherapy and parenteral nutrition for three weeks, who developed a severe lactic acidosis. Clinical features included both digestive and neurological disorders associated with a moderate cardiovascular collapse. After elimination of a toxic, a neoplastic or a septic cause, a thiamin (or vitamin B1) deficiency was suspected because of the lack of vitamin supply to parenteral nutrition. Intravenous administration of thiamin rapidly controlled lactic and clinical features. The diagnosis was confirmed by a low plasmatic concentration of thiamin. Thiamin deficiency must be suspected in case of severe lactic acidosis during parenteral nutrition and systematically prevented by supply of vitamins(12).
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Sources
(12) http://www.ncbi.nlm.nih.gov/pubmed/10365207
http://medicaladvisorjournals.blogspot.com
2012-08-24 04:41:36
Source: http://medicaladvisorjournals.blogspot.com/2012/08/severe-lactic-acidosis-and-vitamin-b1.html
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