Vitamin B1 and diastolic dysfunction and heart failure

Home of Kyle J. Norton for The Better of Living & Living Health The vitamin B-complex are essential water-soluble vitamins, including vitamin B1(thiamine), vitamin B2 (riboflavin ), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), biotin, folic acid and vitamin B12 (cobalamins).

A. Vitamin B1 (Thiamine)
 Vitamin B1 and diastolic dysfunction and heart failure
In the study to determine whether the activity of the Akt/Pim-1 signaling pathway is altered at critical stages of diabetic cardiomyopathy and whether supplementation with vitamin B1 analog benfotiamine (BFT) helps to sustain the above prosurvival mechanism, researchers at the University of Bristol, indicated that  benfotiamine (BFT) improved cardiac perfusion and reduced cardiomyocyte apoptosis and interstitial fibrosis. In hearts of untreated diabetic mice, the expression and activity of Akt/Pim-1 signaling declined along with O-N-acetylglucosamine modification of Akt, inhibition of pentose phosphate pathway, activation of oxidative stress, and accumulation of glycation end products. Furthermore, diabetes reduced pSTAT3 independently of Akt. BFT inhibited these effects of diabetes mellitus, thereby conferring cardiomyocytes with improved resistance to high glucose-induced damage(4).

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Sources
(4) http://www.ncbi.nlm.nih.gov/pubmed/20107192

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