Biotin deficiency and chronic inflammatory diseases

Home of Kyle J. Norton for The Better of Living & Living Health The vitamin B-complex are essential water-soluble vitamins, including vitamin B1(thiamine), vitamin B2 (riboflavin ), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), biotin, folic acid and vitamin B12 (cobalamins).
Biotin (Vitamin H or coenzyme R), a water solubale vitamin and member of vitamin B complex, plays an important role in cell growth and in the metabolism of fats acids and amino acids such as isoleucine, and valine, and in in the generation of glucose from non-carbohydrate carbon substrates.
Biotin deficiency
Biotin deficiency and chronic inflammatory diseases
In the study to investigate the effects of biotin deficiency on TNF-alpha production with mice fed a basal diet or a biotin-deficient diet for 8 weeks, showed that biotin deficiency may up-regulate TNF-alpha production or that biotin excess down-regulates TNF-alpha production, suggesting that biotin status may influence inflammatory diseases(16).

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